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HomoloGene:7594. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   VCL,  H.sapiens
vinculin
    NP_054706.1
1134 aa
   VCL,  P.troglodytes
vinculin
    XP_507854.2
1134 aa
   VCL,  M.mulatta
vinculin
    XP_001118118.1
547 aa
   VCL,  C.lupus
vinculin
    XP_536395.3
1170 aa
   VCL,  B.taurus
vinculin
    NP_001178299.1
1134 aa
   Vcl,  M.musculus
vinculin
    NP_033528.3
1066 aa
   Vcl,  R.norvegicus
vinculin
    NP_001100718.1
1066 aa
   VCL,  G.gallus
vinculin
    NP_990772.1
1066 aa
   vcl,  X.tropicalis
vinculin
    NP_001090722.1
1065 aa
   vcla,  D.rerio
vinculin a
    NP_001122153.1
1131 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cardiomyopathy, dilated, 1W.



Publications
Articles associated with genes and sequences of this homology group.

How vinculin regulates force transmission.
Dumbauld DW, et al. Proc Natl Acad Sci U S A 110, 9788-93 (2013).
Novel role for vinculin in ventricular myocyte mechanics and dysfunction.
Tangney JR, et al. Biophys J 104, 1623-33 (2013).
Metavinculin: New insights into functional properties of a muscle adhesion protein.
Thoss F, et al. Biochem Biophys Res Commun 430, 7-13 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Vinculin (pfam01044)
  Vinculin family.
Vinculin (pfam01044)
  Vinculin family.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vcl includes H.sapiens VCL and R.norvegicus Vcl.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 10 species)
Actinopterygii - bony fishes (13 transcripts, 5 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

 

 

 

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