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HomoloGene:74545. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   EGFR,  H.sapiens
epidermal growth factor receptor
    NP_005219.2
1210 aa
   EGFR,  P.troglodytes
epidermal growth factor receptor
    XP_519102.3
1210 aa
   EGFR,  M.mulatta
epidermal growth factor receptor
    XP_001107305.1
1120 aa
   EGFR,  C.lupus
epidermal growth factor receptor
    XP_533073.3
1180 aa
   EGFR,  B.taurus
epidermal growth factor receptor
    XP_002696936.2
1208 aa
   Egfr,  M.musculus
epidermal growth factor receptor
    NP_997538.1
1210 aa
   Egfr,  R.norvegicus
epidermal growth factor receptor
    NP_113695.1
1209 aa
   EGFR,  G.gallus
epidermal growth factor receptor
    NP_990828.2
1226 aa
   egfr,  X.tropicalis
epidermal growth factor receptor
    XP_002939960.2
1210 aa
   egfra,  D.rerio
epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
    NP_919405.1
1191 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Adenocarcinoma of lung, response to tyrosine kinase inhibitor in.
Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in.
Nonsmall cell lung cancer, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Syntroph_Cxxx (TIGR04117)
  Syntrophus aciditrophicus Cys-Xaa-Xaa-Xaa repeat radical SAM target protein.
TM_EGFR-like (cl17045)
  Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases.
Recep_L_domain (pfam01030)
  Receptor L domain.
FU (cl00066)
  Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Recep_L_domain (pfam01030)
  Receptor L domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Egfr includes H.sapiens EGFR and R.norvegicus Egfr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 12 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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