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HomoloGene:88330. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

HFE,  H.sapiens
hemochromatosis
NP_000401.1
348 aa
HFE,  P.troglodytes
hemochromatosis
NP_001009101.1
348 aa
HFE,  M.mulatta
hemochromatosis
XP_001085245.2
348 aa
HFE,  C.lupus
hemochromatosis
XP_003434224.2
504 aa
HFE,  B.taurus
hemochromatosis
NP_001012399.1
356 aa
Hfe,  M.musculus
hemochromatosis
NP_034554.2
359 aa
Hfe,  R.norvegicus
hemochromatosis
NP_445753.1
360 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Porphyria variegata.
Hemochromatosis.



Publications
Articles associated with genes and sequences of this homology group.

Meta-analysis on the association between the TF gene rs1049296 and AD.
Wang Y, et al. Can J Neurol Sci 40, 691-7 (2013).
The prevalence of primary hereditary hemochromatosis in central Anatolia.
Karaca H, et al. Turk J Gastroenterol 24, 43-50 (2013).
Meta-analyses of HFE variants in coronary heart disease.
Lian J, et al. Gene 527, 167-73 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MHC_I (pfam00129)
  Class I Histocompatibility antigen, domains alpha 1 and 2.
MHC_I (cl08246)
  Class I Histocompatibility antigen, domains alpha 1 and 2.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hfe includes H.sapiens HFE and R.norvegicus Hfe.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)

 

 

 

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