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HomoloGene:527. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   BCL2,  H.sapiens
B-cell CLL/lymphoma 2
239 aa
   BCL2,  P.troglodytes
B-cell CLL/lymphoma 2
239 aa
   BCL2,  C.lupus
B-cell CLL/lymphoma 2
239 aa
   BCL2,  B.taurus
B-cell CLL/lymphoma 2
229 aa
   Bcl2,  M.musculus
B cell leukemia/lymphoma 2
236 aa
   Bcl2,  R.norvegicus
B-cell CLL/lymphoma 2
236 aa
   BCL2,  G.gallus
B-cell CLL/lymphoma 2
232 aa
   bcl2,  X.tropicalis
B-cell CLL/lymphoma 2
293 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Leukemia/lymphoma, B-cell, 2.

Articles associated with genes and sequences of this homology group.

Bcl-2 gene expression in human breast cancers in iran.
Rostamizadeh L, et al. Asian Pac J Cancer Prev 14, 4209-14 (2013).
Bcl-2 level as a biomarker for 13q14 deletion in CLL.
Degheidy HA, et al. Cytometry B Clin Cytom 84, 237-47 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Bcl-2_like (cd06845)
  Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
BH4 (cl02540)
  Bcl-2 homology region 4.
bcl-2 (TIGR00865)
  apoptosis regulator.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bcl2 includes H.sapiens BCL2 and R.norvegicus Bcl2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 11 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Hirudinida - segmented worms (1 transcript, 1 species)




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