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HomoloGene:2220. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RXRA,  H.sapiens
retinoid X receptor, alpha
    NP_002948.1
462 aa
   RXRA,  P.troglodytes
retinoid X receptor, alpha
    XP_520345.4
365 aa
   RXRA,  C.lupus
retinoid X receptor, alpha
    XP_005625216.1
486 aa
   RXRA,  B.taurus
retinoid X receptor, alpha
    XP_005213562.1
486 aa
   Rxra,  M.musculus
retinoid X receptor alpha
    NP_035435.1
467 aa
   Rxra,  R.norvegicus
retinoid X receptor alpha
    NP_036937.2
467 aa
   RXRA,  G.gallus
retinoid X receptor, alpha
    XP_003642339.1
467 aa
   rxra,  X.tropicalis
retinoid X receptor, alpha
    XP_004916703.1
479 aa
   rxraa,  D.rerio
retinoid X receptor, alpha a
    NP_001155023.1
458 aa
   usp,  D.melanogaster
ultraspiracle
    NP_001259168.1
508 aa
   AgaP_AGAP002095,  A.gambiae
AgaP_AGAP002095
    XP_003436029.1
515 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Encodes a protein that binds the promoter region of Cp15. Mutants are recessive lethals. usp/usp or usp/γ progeny of usp/+ mothers die during the first larval instar or in the molt to the second instar. Those that die during the molt to the second instar sometimes have incompletely molted the first instar set of larval spiracles and thus have two sets of spiracles (Perrimon, Engstrom and Mahowald, 1985; Oro, McKeown and Evans, 1992). usp/Y embryos derived from usp/usp germ cells die just prior to or just after hatching with an oval scar on the ventral surface of the posterior eighth abdominal or ninth abdominal segment. (See FlyBase for complete description.)



Publications
Articles associated with genes and sequences of this homology group.

Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers.
Putcha BD, et al. Proc Natl Acad Sci U S A 109, 6084-7 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Nuc_recep-AF1 (pfam11825)
  Nuclear/hormone receptor activator site AF-1.
Nuc_recep-AF1 (pfam11825)
  Nuclear/hormone receptor activator site AF-1.
NR_DBD_like (cl02596)
  DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397)
  The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rxra includes H.sapiens RXRA and R.norvegicus Rxra.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 9 species)
Actinopterygii - bony fishes (10 transcripts, 6 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (5 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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