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HomoloGene:84. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DLD,  H.sapiens
dihydrolipoamide dehydrogenase
    NP_000099.2
509 aa
   DLD,  P.troglodytes
dihydrolipoamide dehydrogenase
    XP_001165051.2
538 aa
   DLD,  M.mulatta
dihydrolipoamide dehydrogenase
    XP_001095232.2
486 aa
   DLD,  C.lupus
dihydrolipoamide dehydrogenase
    NP_001003294.1
509 aa
   DLD,  B.taurus
dihydrolipoamide dehydrogenase
    NP_001193099.1
509 aa
   Dld,  M.musculus
dihydrolipoamide dehydrogenase
    NP_031887.2
509 aa
   Dld,  R.norvegicus
dihydrolipoamide dehydrogenase
    NP_955417.1
509 aa
   DLD,  G.gallus
dihydrolipoamide dehydrogenase
    NP_001025898.1
508 aa
   dld,  X.tropicalis
dihydrolipoamide dehydrogenase
    XP_002933161.2
509 aa
   dldh,  D.rerio
dihydrolipoamide dehydrogenase
    NP_958914.1
507 aa
   CG7430,  D.melanogaster
CG7430
    NP_649017.1
504 aa
   AgaP_AGAP011629,  A.gambiae
AgaP_AGAP011629
    XP_320877.4
433 aa
   dld-1,  C.elegans
dld-1
    NP_001255810.1
495 aa
   LPD1,  S.cerevisiae
LPD1
    NP_116635.1
499 aa
   KLLA0D11154g,  K.lactis
KLLA0D11154g
    XP_453559.1
493 aa
   AGOS_AFR512W,  E.gossypii
AGOS_AFR512W
    NP_986059.2
496 aa
   dld1,  S.pombe
dld1
    NP_593496.1
511 aa
   MGG_17072,  M.oryzae
MGG_17072
    XP_003716343.1
508 aa
   NCU02407,  N.crassa
NCU02407
    XP_959535.2
504 aa
   mtLPD1,  A.thaliana
mtLPD1
    NP_175237.1
507 aa
   mtLPD2,  A.thaliana
mtLPD2
    NP_566570.3
507 aa
   Os01g0328700,  O.sativa
Os01g0328700
    NP_001042918.1
503 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Maple syrup urine disease, type III.
Leigh syndrome.



Publications
Articles associated with genes and sequences of this homology group.

A core metabolic enzyme mediates resistance to phosphine gas.
Schlipalius DI, et al. Science 338, 807-10 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NAD_binding_8 (pfam13450)
  NAD(P)-binding Rossmann-like domain.
Pyr_redox (pfam00070)
  Pyridine nucleotide-disulphide oxidoreductase.
Pyr_redox_dim (pfam02852)
  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain.
NADB_Rossmann (cl09931)
  Rossmann-fold NAD(P)(+)-binding proteins.
Glycosyltransferase_GTB_type (cl10013)
  Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
Pyr_redox (pfam00070)
  Pyridine nucleotide-disulphide oxidoreductase.
Pyr_redox_dim (pfam02852)
  Pyridine nucleotide-disulphide oxidoreductase, dimerization domain.
Glycosyltransferase_GTB_type (cl10013)
  Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
NAD_binding_8 (cl19134)
  NAD(P)-binding Rossmann-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dld includes H.sapiens DLD and R.norvegicus Dld.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 16 species)
Actinopterygii - bony fishes (17 transcripts, 11 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (16 transcripts, 12 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (59 transcripts, 34 species)
Liliopsida - monocots (22 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Oomycetes
Pythiales - oomycetes (2 transcripts, 1 species)
Peronosporales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (3 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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