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HomoloGene:3228. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   VCAN,  H.sapiens
versican
    NP_004376.2
3396 aa
   VCAN,  P.troglodytes
versican
    XP_517667.2
3396 aa
   VCAN,  M.mulatta
versican
    XP_001112269.1
3398 aa
   VCAN,  C.lupus
versican
    XP_003434465.1
3401 aa
   VCAN,  B.taurus
versican
    NP_851378.1
3381 aa
   Vcan,  M.musculus
versican
    NP_001074718.1
3354 aa
   Vcan,  R.norvegicus
versican
    NP_001164029.1
3357 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Wagner syndrome 1.



Publications
Articles associated with genes and sequences of this homology group.

A family with Wagner syndrome with uveitis and a new versican mutation.
Rothschild PR, et al. Mol Vis 19, 2040-9 (2013).
De novo splice mutation in the versican gene in a family with Wagner syndrome.
Rothschild PR, et al. JAMA Ophthalmol 131, 805-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LAP1C (pfam05609)
  Lamina-associated polypeptide 1C (LAP1C).
Link_Domain (cl02612)
  The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...
CCP (cl00043)
  SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
CLECT (cl02432)
  C-type lectin (CTL)/C-type lectin-like (CTLD) domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vcan includes H.sapiens VCAN and R.norvegicus Vcan.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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