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HomoloGene:933. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

BUB1B,  H.sapiens
BUB1 mitotic checkpoint serine/threonine kinase B
NP_001202.4
1050 aa
BUB1B,  P.troglodytes
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
XP_510299.3
1050 aa
BUB1B,  M.mulatta
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
XP_002804771.1
1054 aa
BUB1B,  C.lupus
BUB1 mitotic checkpoint serine/threonine kinase B
XP_850443.2
1062 aa
BUB1B,  B.taurus
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
NP_001138645.1
1062 aa
Bub1b,  M.musculus
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
NP_033903.2
1052 aa
Bub1b,  R.norvegicus
BUB1 mitotic checkpoint serine/threonine kinase B
XP_342495.4
1052 aa
BUB1B,  G.gallus
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
NP_989734.1
1085 aa
bub1b,  X.tropicalis
BUB1 mitotic checkpoint serine/threonine kinase B
NP_001096484.1
411 aa
bub1bb,  D.rerio
budding uninhibited by benzimidazoles 1 homolog beta b
XP_695384.3
427 aa
BUBR1,  A.thaliana
BUBR1
NP_565767.1
395 aa
Os02g0193600,  O.sativa
Os02g0193600
NP_001046171.1
398 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Colorectal cancer.



Publications
Articles associated with genes and sequences of this homology group.

The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.
Suijkerbuijk SJ, et al. Dev Cell 22, 1321-9 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Trichoplein (pfam13868)
  Tumour suppressor, Mitostatin.
PRK14879 (PRK14879)
  serine/threonine protein kinase; Provisional.
Mad3_BUB1_I (cl07066)
  Mad3/BUB1 homology region 1.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
rRNA_processing (pfam08524)
  rRNA processing.
CAF-1_p150 (pfam11600)
  Chromatin assembly factor 1 complex p150 subunit, N-terminal.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Bub1b includes H.sapiens BUB1B and R.norvegicus Bub1b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 12 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (13 transcripts, 13 species)
Liliopsida - monocots (3 transcripts, 3 species)
Coniferopsida - conifers (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

 

 

 

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