Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:20146. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HEXA,  H.sapiens
hexosaminidase A (alpha polypeptide)
    NP_000511.2
529 aa
   HEXA,  P.troglodytes
hexosaminidase A (alpha polypeptide)
    XP_001175124.1
529 aa
   HEXA,  M.mulatta
hexosaminidase A (alpha polypeptide)
    XP_001092589.1
529 aa
   HEXA,  C.lupus
hexosaminidase A (alpha polypeptide)
    XP_544758.2
529 aa
   HEXA,  B.taurus
hexosaminidase A (alpha polypeptide)
    NP_001068632.1
529 aa
   Hexa,  M.musculus
hexosaminidase A
    NP_034551.2
528 aa
   Hexa,  R.norvegicus
hexosaminidase A
    NP_001004443.1
528 aa
   HEXA,  G.gallus
hexosaminidase A (alpha polypeptide)
    NP_001025561.1
526 aa
   zgc:112084,  D.rerio
zgc:112084
    NP_001017763.1
532 aa
   HEXO3,  A.thaliana
HEXO3
    NP_176737.2
535 aa
   Os05g0415700,  O.sativa
Os05g0415700
    NP_001055557.1
531 aa
   Os01g0891000,  O.sativa
Os01g0891000
    NP_001045052.1
526 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
GM2-gangliosidosis, several forms.
Hex A pseudodeficiency.
Tay-Sachs disease.



Publications
Articles associated with genes and sequences of this homology group.

Hexosaminidase A Deficiency
Kaback MM, et al. (1993).
Hexosaminidase as a new potential marker for larynx cancer.
Olszewska E, et al. Clin Biochem 42, 1187-9 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Glyco_hydro_20b (pfam02838)
  Glycosyl hydrolase family 20, domain 2.
GH20_hexosaminidase (cl02948)
  Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. ...
Glyco_hydro_20b (cl03741)
  Glycosyl hydrolase family 20, domain 2.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hexa includes H.sapiens HEXA and R.norvegicus Hexa.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 15 species)
Actinopterygii - bony fishes (6 transcripts, 6 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (3 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 1 species)

Arthropoda
Arachnida - arachnids (5 transcripts, 2 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (2 transcripts, 1 species)
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (25 transcripts, 20 species)
Liliopsida - monocots (16 transcripts, 9 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (5 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

Write to the Help Desk