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HomoloGene:226. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NF1,  H.sapiens
neurofibromin 1
    NP_001035957.1
2839 aa
   NF1,  P.troglodytes
neurofibromin 1
    XP_511395.2
2839 aa
   NF1,  M.mulatta
neurofibromin 1
    XP_002800429.1
2690 aa
   NF1,  C.lupus
neurofibromin 1
    XP_537738.3
2824 aa
   Nf1,  M.musculus
neurofibromatosis 1
    NP_035027.1
2841 aa
   Nf1,  R.norvegicus
neurofibromin 1
    NP_036741.1
2820 aa
   NF1,  G.gallus
neurofibromin 1
    XP_004946843.1
2848 aa
   nf1,  X.tropicalis
neurofibromin 1
    XP_002936865.2
2785 aa
   nf1b,  D.rerio
neurofibromin 1b
    XP_692937.4
2750 aa
   Nf1,  D.melanogaster
Neurofibromin 1
    NP_733132.2
2802 aa
   AgaP_AGAP003140,  A.gambiae
AgaP_AGAP003140
    XP_312829.4
2790 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Melanoma, desmoplastic neurotropic.
Neurofibromatosis, type 1.
Pseudarthrosis, tibial, in NF1.
Neurofibromatosis, familial spinal.
Watson syndrome.
Neurofibromatosis-Noonan syndrome.
Leukemia, juvenile myelomonocytic.



Publications
Articles associated with genes and sequences of this homology group.

Neurofibromin is the major ras inactivator in dendritic spines.
Oliveira AF & Yasuda R. J Neurosci 34, 776-83 (2014).
Ras-Mek-Erk signaling regulates Nf1 heterozygous neointima formation.
Stansfield BK, et al. Am J Pathol 184, 79-85 (2014).
NF1 is a critical regulator of muscle development and metabolism.
Sullivan K, et al. Hum Mol Genet 23, 1250-9 (2014).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MOR2-PAG1_mid (pfam14228)
  Cell morphogenesis central region.
RasGAP (cl02569)
  Ras GTPase Activating Domain.
SEC14 (cl15787)
  Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nf1 includes H.sapiens NF1 and R.norvegicus Nf1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (30 transcripts, 10 species)
Actinopterygii - bony fishes (20 transcripts, 6 species)
Amniota - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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