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HomoloGene:38290. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SLC6A14,  H.sapiens
solute carrier family 6 (amino acid transporter), member 14
    NP_009162.1
642 aa
   SLC6A14,  P.troglodytes
solute carrier family 6 (amino acid transporter), member 14
    XP_003317696.1
604 aa
   SLC6A14,  M.mulatta
solute carrier family 6 (amino acid transporter), member 14
    XP_001104391.1
642 aa
   SLC6A14,  C.lupus
solute carrier family 6 (amino acid transporter), member 14
    XP_549207.2
639 aa
   SLC6A14,  B.taurus
solute carrier family 6 (amino acid transporter), member 14
    NP_001091931.1
640 aa
   Slc6a14,  M.musculus
solute carrier family 6 (neurotransmitter transporter), member 14
    NP_064433.3
638 aa
   Slc6a14,  R.norvegicus
solute carrier family 6 (amino acid transporter), member 14
    NP_001032633.1
640 aa
   SLC6A14,  G.gallus
solute carrier family 6 (amino acid transporter), member 14
    XP_003641183.1
640 aa
   slc6a14.1,  X.tropicalis
solute carrier family 6 (amino acid transporter), member 14, gene 1
    XP_002939712.2
634 aa
   slc6a14,  D.rerio
solute carrier family 6 (amino acid transporter), member 14
    XP_001923596.1
614 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Obesity, susceptibility to.
Obesity, susceptibility to, X-linked.



Publications
Articles associated with genes and sequences of this homology group.

Protein kinase C regulates amino acid transporter ATB(0,+).
Samluk L, et al. Biochem Biophys Res Commun 422, 64-9 (2012).
Human solute carrier SLC6A14 is the beta-alanine carrier.
Anderson CM, et al. J Physiol 586, 4061-7 (2008).
The SLC6A14 gene shows evidence of association with obesity.
Suviolahti E, et al. J Clin Invest 112, 1762-72 (2003).
Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal.
Sloan JL, et al. Am J Physiol Lung Cell Mol Physiol 284, L39-49 (2003).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SLC5-6-like_sbd (cl00456)
  Solute carrier families 5 and 6-like; solute binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Slc6a14 includes H.sapiens SLC6A14 and R.norvegicus Slc6a14.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 6 species)
Ascidiacea - tunicates (6 transcripts, 3 species)
Cephalochordata - lancelets (3 transcripts, 1 species)
Amphibia - amphibians (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (4 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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