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HomoloGene:3911. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LCK,  H.sapiens
lymphocyte-specific protein tyrosine kinase
    NP_001036236.1
509 aa
   LCK,  P.troglodytes
lymphocyte-specific protein tyrosine kinase
    XP_003307997.2
470 aa
   LCK,  C.lupus
lymphocyte-specific protein tyrosine kinase
    XP_005617696.1
509 aa
   LCK,  B.taurus
lymphocyte-specific protein tyrosine kinase
    NP_001029506.1
509 aa
   Lck,  M.musculus
lymphocyte protein tyrosine kinase
    NP_001155904.1
520 aa
   Lck,  R.norvegicus
lymphocyte-specific protein tyrosine kinase
    NP_001094179.1
509 aa
   LCK,  G.gallus
lymphocyte-specific protein tyrosine kinase
    XP_004947872.1
545 aa
   lck,  X.tropicalis
lymphocyte-specific protein tyrosine kinase
    XP_002939341.2
509 aa
   lck,  D.rerio
lymphocyte-specific protein tyrosine kinase
    NP_001001596.1
503 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
SCID due to LCK deficiency.



Publications
Articles associated with genes and sequences of this homology group.

The role of membrane rafts in Lck transport, regulation and signalling in T-cells.
Ventimiglia LN & Alonso MA. Biochem J 454, 169-79 (2013).
Cytoskeletal modulation of lipid interactions regulates Lck kinase activity.
Chichili GR, et al. J Biol Chem 287, 24186-94 (2012).
The role of L(u)ck in T cell triggering.
Berry R. Sci Signal 4, jc2 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lck includes H.sapiens LCK and R.norvegicus Lck.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (15 transcripts, 10 species)
Mammalia - mammals (13 transcripts, 11 species)
Aves - birds (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

 

 

 

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