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HomoloGene:199. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LIPC,  H.sapiens
lipase, hepatic
    NP_000227.2
499 aa
   LIPC,  P.troglodytes
lipase, hepatic
    XP_001172241.1
499 aa
   LIPC,  M.mulatta
lipase, hepatic
    XP_001095252.1
499 aa
   LIPC,  C.lupus
lipase, hepatic
    XP_535495.3
501 aa
   LIPC,  B.taurus
lipase, hepatic
    NP_001030487.1
500 aa
   Lipc,  M.musculus
lipase, hepatic
    NP_032306.2
510 aa
   Lipc,  R.norvegicus
lipase, hepatic
    NP_036729.2
494 aa
   LIPC,  G.gallus
lipase, hepatic
    XP_425067.4
496 aa
   lipc,  X.tropicalis
lipase, hepatic
    NP_001107731.1
496 aa
   lipca,  D.rerio
lipase, hepatic a
    NP_957316.1
514 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hepatic lipase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Association of LIPC and advanced age-related macular degeneration.
Lee J, et al. Eye (Lond) 27, 265-70; quiz 271 (2013).
Prognostic value of LIPC in non-small cell lung carcinoma.
Galluzzi L, et al. Cell Cycle 12, 647-54 (2013).
Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer.
Crous-Bou M, et al. Mutagenesis 27, 169-76 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PLAT (cl00011)
  PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
Lipase (cl14883)
  Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lipc includes H.sapiens LIPC and R.norvegicus Lipc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Amphibia - amphibians (3 transcripts, 2 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

 

 

 

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