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HomoloGene:585. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CD3D,  H.sapiens
CD3d molecule, delta (CD3-TCR complex)
    NP_000723.1
171 aa
   CD3D,  P.troglodytes
CD3d molecule, delta (CD3-TCR complex)
    XP_508789.2
171 aa
   CD3D,  M.mulatta
CD3d molecule, delta (CD3-TCR complex)
    XP_001097302.1
171 aa
   CD3D,  C.lupus
CD3d molecule, delta (CD3-TCR complex)
    XP_536556.1
171 aa
   CD3D,  B.taurus
CD3d molecule, delta (CD3-TCR complex)
    NP_001029205.1
168 aa
   Cd3d,  M.musculus
CD3 antigen, delta polypeptide
    NP_038515.3
173 aa
   Cd3d,  R.norvegicus
CD3 molecule, delta
    NP_037301.1
173 aa
   CD3D,  G.gallus
CD3d molecule, delta (CD3-TCR complex)
    NP_990843.1
175 aa
   cd3g,  X.tropicalis
CD3g molecule, gamma (CD3-TCR complex)
    NP_001135555.1
164 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Severe combined immunodeficiency, T-negative/B-positive type.



Publications
Articles associated with genes and sequences of this homology group.

Initiation of TCR signaling: regulation within CD3 dimers.
Alarcón B, et al. Immunol Rev 191, 38-46 (2003).
T cell-specific expression of the murine CD3delta promoter.
Ji HB, et al. J Biol Chem 277, 47898-906 (2002).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ITAM (pfam02189)
  Immunoreceptor tyrosine-based activation motif.
ITAM (smart00077)
  Immunoreceptor tyrosine-based activation motif.
Ig (cl11960)
  Immunoglobulin domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cd3d includes H.sapiens CD3D and R.norvegicus Cd3d.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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