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HomoloGene:68393. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CREBBP,  H.sapiens
CREB binding protein
    NP_004371.2
2442 aa
   CREBBP,  P.troglodytes
CREB binding protein
    XP_523285.2
2442 aa
   CREBBP,  M.mulatta
CREB binding protein
    XP_001095225.1
2442 aa
   CREBBP,  C.lupus
CREB binding protein
    XP_003434912.1
2442 aa
   CREBBP,  B.taurus
CREB binding protein
    NP_001157494.1
2435 aa
   Crebbp,  M.musculus
CREB binding protein
    NP_001020603.1
2441 aa
   Crebbp,  R.norvegicus
CREB binding protein
    NP_596872.3
2444 aa
   CREBBP,  G.gallus
CREB binding protein
    XP_004945446.1
2313 aa
   crebbp,  X.tropicalis
CREB binding protein
    NP_001192159.1
2427 aa
   crebbpa,  D.rerio
CREB binding protein a
    XP_005161826.1
2350 aa
   crebbpb,  D.rerio
CREB binding protein b
    XP_005163782.1
2435 aa
   LOC101884291,  D.rerio
CREB-binding protein-like
    XP_005163780.1
1824 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Rubenstein-Taybi syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Rubinstein-Taybi syndrome predisposing to non-WNT, non-SHH, group 3 medulloblastoma.
Bourdeaut F, et al. Pediatr Blood Cancer 61, 383-6 (2014).
The CH2 domain of CBP/p300 is a novel zinc finger.
Park S, et al. FEBS Lett 587, 2506-11 (2013).
Modulation of allostery by protein intrinsic disorder.
Ferreon AC, et al. Nature 498, 390-4 (2013).
Germline mosaicism in Rubinstein-Taybi syndrome.
Tajir M, et al. Gene 518, 476-8 (2013).
Duplication 16p13.3 and the CREBBP gene: confirmation of the phenotype.
Demeer B, et al. Eur J Med Genet 56, 26-31 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
KIX (pfam02172)
  KIX domain.
DEC-1_N (pfam04625)
  DEC-1 protein, N-terminal region.
PTZ00249 (PTZ00249)
  variable surface protein Vir28; Provisional.
DUF902 (pfam06001)
  Domain of Unknown Function (DUF902).
zf-TAZ (pfam02135)
  TAZ zinc finger.
KAT11 (pfam08214)
  Histone acetylation protein.
Fork_head_N (pfam08430)
  Forkhead N-terminal region.
Creb_binding (pfam09030)
  Creb binding.
COG5076 (COG5076)
  Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription].
ZZ (cl00295)
  Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
KIX (pfam02172)
  KIX domain.
DUF902 (pfam06001)
  Domain of Unknown Function (DUF902).
Creb_binding (pfam09030)
  Creb binding.
Med3 (pfam11593)
  Mediator complex subunit 3 fungal.
KAT11 (cl02120)
  Histone acetylation protein.
Bromodomain (cl02556)
  Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
zf-TAZ (cl02660)
  TAZ zinc finger.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Crebbp includes H.sapiens CREBBP and R.norvegicus Crebbp.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (30 transcripts, 9 species)
Mammalia - mammals (17 transcripts, 13 species)
Cephalochordata - lancelets (3 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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