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HomoloGene:4882. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   COPS8,  H.sapiens
COP9 signalosome subunit 8
    NP_006701.1
209 aa
   COPS8,  P.troglodytes
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
    XP_003950051.1
209 aa
   COPS8,  C.lupus
COP9 signalosome subunit 8
    XP_534612.2
209 aa
   COPS8,  B.taurus
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
    NP_001076966.1
209 aa
   Cops8,  M.musculus
COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)
    NP_598566.3
209 aa
   Cops8,  R.norvegicus
COP9 signalosome subunit 8
    NP_001013245.1
209 aa
   COPS8,  G.gallus
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
    NP_001041472.1
207 aa
   cops8,  X.tropicalis
COP9 signalosome subunit 8
    NP_989106.1
193 aa
   cops8,  D.rerio
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
    NP_956523.1
191 aa
   CSN8,  D.melanogaster
COP9 complex homolog subunit 8
    NP_723378.2
182 aa
   AgaP_AGAP008857,  A.gambiae
AgaP_AGAP008857
    XP_319600.4
187 aa
   COP9,  A.thaliana
COP9
    NP_193147.1
197 aa
   Os04g0428900,  O.sativa
Os04g0428900
    NP_001052805.1
196 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Many jobs for one good cop - the COP9 signalosome guards development and defense.
Stratmann JW & Gusmaroli G. Plant Sci 185-186, 50-64 (2012).
COP9 signalosome regulates autophagosome maturation.
Su H, et al. Circulation 124, 2117-28 (2011).
The COP9 signalosome.
Wei N & Deng XW. Annu Rev Cell Dev Biol 19, 261-86 (2003).
Human COP9 subunit 8 homolog gene SGN8 Map position 2q37.
Gizatullin RZ, et al. Chromosome Res 8, 559 (2000).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PCI_Csn8 (pfam10075)
  COP9 signalosome, subunit CSN8.
PCI_Csn8 (pfam10075)
  COP9 signalosome, subunit CSN8.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cops8 includes H.sapiens COPS8 and R.norvegicus Cops8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 13 species)
Actinopterygii - bony fishes (13 transcripts, 11 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 8 species)
Arachnida - arachnids (2 transcripts, 2 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (31 transcripts, 30 species)
Liliopsida - monocots (13 transcripts, 8 species)
Coniferopsida - conifers (2 transcripts, 2 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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