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HomoloGene:128606. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   CXCL12,  H.sapiens
chemokine (C-X-C motif) ligand 12
140 aa
   LOC741624,  P.troglodytes
uncharacterized LOC741624
382 aa
   CXCL12,  M.mulatta
chemokine (C-X-C motif) ligand 12
89 aa
   CXCL12,  C.lupus
chemokine (C-X-C motif) ligand 12
93 aa
   CXCL12,  B.taurus
chemokine (C-X-C motif) ligand 12
89 aa
   Cxcl12,  M.musculus
chemokine (C-X-C motif) ligand 12
119 aa
   Cxcl12,  R.norvegicus
chemokine (C-X-C motif) ligand 12
119 aa
   CXCL12,  G.gallus
chemokine (C-X-C motif) ligand 12
89 aa
   cxcl12,  X.tropicalis
chemokine (C-X-C motif) ligand 12
93 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

AIDS, resistance to.

Articles associated with genes and sequences of this homology group.

The role of inflammatory chemokines in lymphoid neoorganogenesis in breast cancer.
Gantsev SK, et al. Biomed Pharmacother 67, 363-6 (2013).
Regulation of circulating neutrophil numbers under homeostasis and in disease.
Strydom N & Rankin SM. J Innate Immun 5, 304-14 (2013).
Chemokines fluctuate in the progression of primary breast cancer.
Wang J, et al. Eur Rev Med Pharmacol Sci 17, 596-608 (2013).
Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070.
O'Boyle G, et al. Br J Cancer 108, 1634-40 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Chemokine (cl00134)
  Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cxcl12 includes H.sapiens CXCL12 and R.norvegicus Cxcl12.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 9 species)
Amphibia - amphibians (1 transcript, 1 species)




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