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HomoloGene:128756. Gene exclusive to H.sapiens Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   DEFA1B,  H.sapiens
defensin, alpha 1B
94 aa
   DEFA1,  H.sapiens
defensin, alpha 1
94 aa
   DEFA3,  H.sapiens
defensin, alpha 3, neutrophil-specific
94 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Effects of human defensin-α(1)on Trypanosoma cruzi trypomastigotes in vitro.
Kleschenko YE, et al. Bull Exp Biol Med 149, 731-3 (2010).
Defensins in systemic lupus erythematosus.
Froy O & Sthoeger ZM. Ann N Y Acad Sci 1173, 365-9 (2009).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Defensin_propep (pfam00879)
  Defensin propeptide.
Defensin_1 (cl11590)
  Cysteine-rich domains that lyse bacteria, fungi and enveloped viruses by forming multimeric membrane-spanning channels.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (4 transcripts, 2 species)




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