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HomoloGene:37659. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PPP1CB,  H.sapiens
protein phosphatase 1, catalytic subunit, beta isozyme
    NP_996759.1
327 aa
   PPP1CB,  P.troglodytes
protein phosphatase 1, catalytic subunit, beta isozyme
    XP_001161723.1
327 aa
   PPP1CB,  M.mulatta
protein phosphatase 1, catalytic subunit, beta isozyme
    XP_001101844.1
327 aa
   PPP1CB,  C.lupus
protein phosphatase 1, catalytic subunit, beta isozyme
    NP_001003034.1
327 aa
   PPP1CB,  B.taurus
protein phosphatase 1, catalytic subunit, beta isozyme
    NP_001029825.1
327 aa
   Ppp1cb,  M.musculus
protein phosphatase 1, catalytic subunit, beta isoform
    NP_766295.2
327 aa
   Ppp1cb,  R.norvegicus
protein phosphatase 1, catalytic subunit, beta isozyme
    NP_037197.1
327 aa
   PPP1CB,  G.gallus
protein phosphatase 1, catalytic subunit, beta isozyme
    NP_990453.1
327 aa
   ppp1cb,  X.tropicalis
protein phosphatase 1, catalytic subunit, beta isozyme
    NP_001011467.1
327 aa
   ppp1cb,  D.rerio
protein phosphatase 1, catalytic subunit, beta isoform
    NP_001004527.2
327 aa
   flw,  D.melanogaster
flapwing
    NP_001259407.1
330 aa
   AgaP_AGAP003114,  A.gambiae
AgaP_AGAP003114
    XP_312797.5
328 aa
   gsp-1,  C.elegans
gsp-1
    NP_001256250.1
329 aa
   TOPP7,  A.thaliana
TOPP7
    NP_567375.1
322 aa
   TOPP3,  A.thaliana
TOPP3
    NP_176587.1
322 aa
   Os06g0164100,  O.sativa
Os06g0164100
    NP_001056901.1
322 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Wings held in lateral position, instead of dorsally and parallel to substrate as in wild type; thorax has darkened longitudinal stripe; anterior scutellar bristles sometimes missing or doubled; eyes bulging and slightly roughened; head compressed; third antennal joint shortened; unable to fly; jumping ability poor; fibrillar muscles of thorax (dorsoventrals, dorsolongitudinals) are variably abnormal, ranging from disorganized to missing; tergal depressor of trochanter jump muscle is normal in light microscope; behavioral and muscular phenotypes affected by flw2 may be due to primary defect in muscle primordia, concluded from mosaic experiment (Deak, 1977); at least two flw alleles (flw3 and flw4) cause reduced amount of a particular protein from indirect flight muscles (same molecule as that affected by hdp, int, rsd and up mutations) (Deak et al., 1982)..



Publications
Articles associated with genes and sequences of this homology group.

Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia.
Velusamy T, et al. Proc Natl Acad Sci U S A 110, 3035-40 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MPP_superfamily (cl13995)
  metallophosphatase superfamily, metallophosphatase domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ppp1cb includes H.sapiens PPP1CB and R.norvegicus Ppp1cb.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (92 transcripts, 31 species)
Liliopsida - monocots (16 transcripts, 8 species)
Coniferopsida - conifers (15 transcripts, 3 species)
Bryopsida - mosses (5 transcripts, 1 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Chordata
Actinopterygii - bony fishes (26 transcripts, 11 species)
Mammalia - mammals (15 transcripts, 14 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Aves - birds (3 transcripts, 3 species)
Hyperoartia - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (18 transcripts, 13 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (3 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)
Anthozoa - anthozoans (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (8 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (2 transcripts, 2 species)

 

 

 

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