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HomoloGene:3394. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TOP3A,  H.sapiens
topoisomerase (DNA) III alpha
    NP_004609.1
1001 aa
   TOP3A,  P.troglodytes
topoisomerase (DNA) III alpha
    XP_511323.2
1001 aa
   TOP3A,  M.mulatta
topoisomerase (DNA) III alpha
    XP_001095437.2
976 aa
   TOP3A,  C.lupus
topoisomerase (DNA) III alpha
    XP_546656.2
989 aa
   TOP3A,  B.taurus
topoisomerase (DNA) III alpha
    NP_001071443.1
1002 aa
   Top3a,  M.musculus
topoisomerase (DNA) III alpha
    NP_033436.1
1003 aa
   Top3a,  R.norvegicus
topoisomerase (DNA) III alpha
    XP_006246613.1
944 aa
   TOP3A,  G.gallus
topoisomerase (DNA) III alpha
    NP_001025807.1
1020 aa
   top3a,  X.tropicalis
topoisomerase (DNA) III alpha
    XP_002935889.1
1021 aa
   top3a,  D.rerio
topoisomerase (DNA) III alpha
    XP_688695.4
998 aa
   Top3alpha,  D.melanogaster
Topoisomerase 3alpha
    NP_523602.2
1250 aa
   AgaP_AGAP010028,  A.gambiae
AgaP_AGAP010028
    XP_319175.3
1025 aa
   top-3,  C.elegans
top-3
    NP_499558.1
759 aa
   TOP3A,  A.thaliana
TOP3A
    NP_201197.1
926 aa
   Os03g0165000,  O.sativa
Os03g0165000
    NP_001173278.1
928 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.
Wang Y, et al. Proc Natl Acad Sci U S A 99, 12114-9 (2002).
Purification and characterization of human DNA topoisomerase IIIalpha.
Goulaouic H, et al. Nucleic Acids Res 27, 2443-50 (1999).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-C4_Topoisom (pfam01396)
  Topoisomerase DNA binding C4 zinc finger.
zf-GRF (pfam06839)
  GRF zinc finger.
TOP1Ac (cd00186)
  DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
TOP1Ac (cl11986)
  DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
zf-GRF (pfam06839)
  GRF zinc finger.
TOPRIM (cl00718)
  Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Top3a includes H.sapiens TOP3A.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 12 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (7 transcripts, 6 species)
Liliopsida - monocots (4 transcripts, 2 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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