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HomoloGene:10820. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GPHN,  H.sapiens
gephyrin
    NP_065857.1
769 aa
   GPHN,  P.troglodytes
gephyrin
    XP_001135362.2
782 aa
   GPHN,  M.mulatta
gephyrin
    XP_002805147.1
782 aa
   GPHN,  C.lupus
gephyrin
    XP_005623587.1
809 aa
   GPHN,  B.taurus
gephyrin
    XP_005212135.1
791 aa
   Gphn,  M.musculus
gephyrin
    NP_666077.2
772 aa
   Gphn,  R.norvegicus
gephyrin
    NP_074056.2
736 aa
   GPHN,  G.gallus
gephyrin
    NP_001026720.1
736 aa
   gphn,  X.tropicalis
gephyrin
    NP_001096372.1
495 aa
   gphna,  D.rerio
gephyrin a
    NP_001170915.1
834 aa
   gphnb,  D.rerio
gephyrin b
    NP_001165871.1
796 aa
   cin,  D.melanogaster
cinnamon
    NP_726659.1
601 aa
   AgaP_AGAP002800,  A.gambiae
AgaP_AGAP002800
    XP_312114.5
616 aa
   MGG_06109,  M.oryzae
MGG_06109
    XP_003711975.1
668 aa
   NCU09746,  N.crassa
NCU09746
    XP_964448.2
726 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hyperekplexia.
Molybdenum cofactor deficiency, type C.



Publications
Articles associated with genes and sequences of this homology group.

Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes.
Hales CM, et al. J Neuropathol Exp Neurol 72, 1009-15 (2013).
Expression and subcellular distribution of gephyrin in non-neuronal tissues and cells.
Nawrotzki R, et al. Histochem Cell Biol 137, 471-82 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MoeA_N (pfam03453)
  MoeA N-terminal region (domain I and II).
MoCF_BD (cl00451)
  MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gphn includes H.sapiens GPHN and R.norvegicus Gphn.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 14 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 10 species)
Malacostraca - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (15 transcripts, 15 species)
Liliopsida - monocots (7 transcripts, 7 species)
Coniferopsida - conifers (4 transcripts, 3 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)
Bryopsida - mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

 

 

 

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