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HomoloGene:128746. Gene conserved in Amniota Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   AAK1,  H.sapiens
AP2 associated kinase 1
961 aa
   AAK1,  P.troglodytes
AP2 associated kinase 1
963 aa
   AAK1,  C.lupus
AP2 associated kinase 1
946 aa
   Aak1,  M.musculus
AP2 associated kinase 1
959 aa
   Aak1,  R.norvegicus
AP2 associated kinase 1
963 aa
   AAK1,  G.gallus
AP2 associated kinase 1
955 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

A novel AAK1 splice variant functions at multiple steps of the endocytic pathway.
Henderson DM & Conner SD. Mol Biol Cell 18, 2698-706 (2007).
Differential requirements for AP-2 in clathrin-mediated endocytosis.
Conner SD & Schmid SL. J Cell Biol 162, 773-9 (2003).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aak1 includes H.sapiens AAK1 and R.norvegicus Aak1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 9 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)




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