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HomoloGene:4277. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ZMPSTE24,  H.sapiens
zinc metallopeptidase STE24
    NP_005848.2
475 aa
   ZMPSTE24,  P.troglodytes
zinc metallopeptidase STE24 homolog (S. cerevisiae)
    XP_513352.2
475 aa
   ZMPSTE24,  M.mulatta
zinc metallopeptidase STE24 homolog (S. cerevisiae)
    XP_001082852.1
475 aa
   ZMPSTE24,  C.lupus
zinc metallopeptidase STE24
    XP_539577.3
473 aa
   ZMPSTE24,  B.taurus
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
    NP_001179857.1
475 aa
   Zmpste24,  M.musculus
zinc metallopeptidase, STE24
    NP_766288.1
475 aa
   Zmpste24,  R.norvegicus
zinc metallopeptidase STE24
    NP_001101444.1
475 aa
   ZMPSTE24,  G.gallus
zinc metallopeptidase STE24
    XP_417720.1
465 aa
   zmpste24,  X.tropicalis
zinc metallopeptidase STE24
    NP_001017255.1
466 aa
   zmpste24,  D.rerio
zinc metallopeptidase, STE24 homolog
    NP_956186.1
468 aa
   ste24a,  D.melanogaster
prenyl protease type I
    NP_611175.1
451 aa
   AgaP_AGAP004470,  A.gambiae
AgaP_AGAP004470
    XP_313769.4
454 aa
   fce-1,  C.elegans
fce-1
    NP_492582.1
442 aa
   STE24,  S.cerevisiae
STE24
    NP_012651.1
453 aa
   KLLA0D10846g,  K.lactis
KLLA0D10846g
    XP_453545.1
456 aa
   SPAC3H1.05,  S.pombe
SPAC3H1.05
    NP_593547.1
474 aa
   MGG_06951,  M.oryzae
MGG_06951
    XP_003709694.1
459 aa
   NCU03637,  N.crassa
NCU03637
    XP_961364.2
464 aa
   ATSTE24,  A.thaliana
ATSTE24
    NP_567212.1
424 aa
   Os02g0680400,  O.sativa
Os02g0680400
    NP_001047739.1
425 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Restrictive dermopathy, lethal.
Mandibuloacral dysplasia with type B lipodystrophy.



Publications
Articles associated with genes and sequences of this homology group.

The structural basis of ZMPSTE24-dependent laminopathies.
Quigley A, et al. Science 339, 1604-7 (2013).
Structure of the integral membrane protein CAAX protease Ste24p.
Pryor EE Jr, et al. Science 339, 1600-4 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Peptidase_M48 (pfam01435)
  Peptidase family M48.
Peptidase_M48 (cl12018)
  Peptidase family M48.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Zmpste24 includes H.sapiens ZMPSTE24 and R.norvegicus Zmpste24.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (10 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 13 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Streptophyta
Eudicotyledons - eudicots (31 transcripts, 26 species)
Liliopsida - monocots (11 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (7 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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