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HomoloGene:723. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   POMC,  H.sapiens
proopiomelanocortin
    NP_000930.1
267 aa
   POMC,  P.troglodytes
proopiomelanocortin
    XP_003309010.1
268 aa
   POMC,  M.mulatta
proopiomelanocortin
    XP_001082999.1
265 aa
   POMC,  C.lupus
proopiomelanocortin
    XP_849463.3
265 aa
   POMC,  B.taurus
proopiomelanocortin
    NP_776576.1
265 aa
   Pomc,  M.musculus
pro-opiomelanocortin-alpha
    NP_001265512.1
235 aa
   Pomc,  R.norvegicus
proopiomelanocortin
    NP_647542.1
235 aa
   POMC,  G.gallus
proopiomelanocortin
    NP_001026269.1
251 aa
   pomc,  X.tropicalis
proopiomelanocortin
    NP_001011318.1
262 aa
   pomca,  D.rerio
proopiomelanocortin a
    NP_852103.1
222 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
ACTH deficiency.
Obesity, adrenal insufficiency, and red hair.
Abdominal body fat distribution, modifier of.



Publications
Articles associated with genes and sequences of this homology group.

Proopiomelanocortin Deficiency
Challis BG, et al. (1993).
The central CLOCK system and the stress axis in health and disease.
Kassi EN & Chrousos GP. Hormones (Athens) 12, 172-91 (2013).
Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish.
De Marco RJ, et al. Front Neural Circuits 7, 82 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NPP (pfam08384)
  Pro-opiomelanocortin, N-terminal region.
ACTH_domain (pfam00976)
  Corticotropin ACTH domain.
Op_neuropeptide (pfam08035)
  Opioids neuropeptide.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pomc includes H.sapiens POMC and R.norvegicus Pomc.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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