Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:37327. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NOS1,  H.sapiens
nitric oxide synthase 1 (neuronal)
    NP_000611.1
1434 aa
   NOS1,  P.troglodytes
nitric oxide synthase 1 (neuronal)
    XP_003314004.2
1448 aa
   NOS1,  M.mulatta
nitric oxide synthase 1 (neuronal)
    XP_001083352.2
1401 aa
   NOS1,  C.lupus
nitric oxide synthase 1 (neuronal)
    NP_001182074.1
1431 aa
   NOS1,  B.taurus
nitric oxide synthase 1 (neuronal)
    XP_002694631.3
1420 aa
   Nos1,  M.musculus
nitric oxide synthase 1, neuronal
    NP_032738.1
1429 aa
   Nos1,  R.norvegicus
nitric oxide synthase 1, neuronal
    NP_434686.1
1463 aa
   NOS1,  G.gallus
nitric oxide synthase 1 (neuronal)
    XP_004934537.1
1435 aa
   nos1,  X.tropicalis
nitric oxide synthase 1 (neuronal)
    XP_004910558.1
1420 aa
   nos1,  D.rerio
nitric oxide synthase 1 (neuronal)
    NP_571735.1
1431 aa
   Nos,  D.melanogaster
Nitric oxide synthase
    NP_523541.2
1349 aa
   AgaP_AGAP008255,  A.gambiae
AgaP_AGAP008255
    XP_317213.1
1113 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pyloric stenosis, infantile hypertrophic, 1, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Nitric oxide mediates local activity-dependent excitatory synapse development.
Nikonenko I, et al. Proc Natl Acad Sci U S A 110, E4142-51 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHA00666 (PHA00666)
  putative protease.
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
NOS_oxygenase (cl00254)
  Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an ...
FMN_red (cl00438)
  NADPH-dependent FMN reductase.
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nos1 includes H.sapiens NOS1 and R.norvegicus Nos1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 10 species)
Actinopterygii - bony fishes (11 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (14 transcripts, 6 species)
Arachnida - arachnids (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

 

 

 

Write to the Help Desk