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HomoloGene:20926. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   DVL1,  H.sapiens
dishevelled segment polarity protein 1
670 aa
   DVL1,  P.troglodytes
dishevelled, dsh homolog 1 (Drosophila)
670 aa
   DVL1,  C.lupus
dishevelled segment polarity protein 1
700 aa
   DVL1,  B.taurus
dishevelled, dsh homolog 1 (Drosophila)
700 aa
   Dvl1,  M.musculus
dishevelled, dsh homolog 1 (Drosophila)
695 aa
   Dvl1,  R.norvegicus
dishevelled segment polarity protein 1
695 aa
   DVL1,  G.gallus
dishevelled, dsh homolog 1 (Drosophila)
748 aa
   dvl1,  X.tropicalis
dishevelled segment polarity protein 1
559 aa
   dvl1b,  D.rerio
dishevelled, dsh homolog 1b (Drosophila)
707 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Dishevelled (pfam02377)
  Dishevelled specific domain.
DIX (cl02426)
  DIX domain.
Dsh_C (pfam12316)
  Segment polarity protein dishevelled (Dsh) C terminal.
Dsh_C (pfam12316)
  Segment polarity protein dishevelled (Dsh) C terminal.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
DIX (cl02426)
  DIX domain.
DEP (cl02442)
  DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dvl1 includes H.sapiens DVL1 and R.norvegicus Dvl1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Trematoda - flatworms (2 transcripts, 1 species)

Insecta - insects (1 transcript, 1 species)

Chromadorea - nematodes (1 transcript, 1 species)




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