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HomoloGene:32157. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SETDB1,  H.sapiens
SET domain, bifurcated 1
NP_001138887.1
1291 aa
SETDB1,  P.troglodytes
SET domain, bifurcated 1
XP_524864.3
1291 aa
SETDB1,  M.mulatta
SET domain, bifurcated 1
XP_001106711.2
1290 aa
SETDB1,  C.lupus
SET domain, bifurcated 1
XP_540304.4
1305 aa
SETDB1,  B.taurus
SET domain, bifurcated 1
NP_001178317.1
1290 aa
Setdb1,  M.musculus
SET domain, bifurcated 1
NP_061365.3
1308 aa
Setdb1,  R.norvegicus
SET domain, bifurcated 1
NP_001258104.1
1302 aa
LOC101751150,  G.gallus
histone-lysine N-methyltransferase SETDB1-like
XP_004948398.1
917 aa
setdb1,  X.tropicalis
SET domain, bifurcated 1
NP_001238764.1
1284 aa
setdb1b,  D.rerio
SET domain, bifurcated 1b
NP_001070745.2
1214 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Regulated nuclear entry of over-expressed Setdb1.
Cho S, et al. Genes Cells 18, 694-703 (2013).
Histone H3-K9 methyltransferase ESET is essential for early development.
Dodge JE, et al. Mol Cell Biol 24, 2478-86 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pre-SET (pfam05033)
  Pre-SET motif.
MBD (cl00110)
  MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
SET (cl02566)
  SET domain.
TUDOR (cl02573)
  Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
Pre-SET (cl02622)
  Pre-SET motif.
SEEEED (cl19208)
  Serine-rich region of AP3B1, clathrin-adaptor complex.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Setdb1 includes H.sapiens SETDB1 and R.norvegicus Setdb1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 10 species)
Actinopterygii - bony fishes (12 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Arachnida - arachnids (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

 

 

 

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