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HomoloGene:3699. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RELN,  H.sapiens
reelin
    NP_005036.2
3460 aa
   RELN,  P.troglodytes
reelin
    XP_519291.3
3460 aa
   RELN,  M.mulatta
reelin
    XP_001087945.1
3460 aa
   RELN,  C.lupus
reelin
    XP_849464.1
3474 aa
   RELN,  B.taurus
reelin-like
    NP_001193387.1
3460 aa
   Reln,  M.musculus
reelin
    NP_035391.2
3461 aa
   Reln,  R.norvegicus
reelin
    NP_536319.2
3462 aa
   RELN,  G.gallus
reelin
    XP_425424.3
3462 aa
   reln,  X.tropicalis
reelin
    NP_001131084.1
3463 aa
   reln,  D.rerio
reelin
    NP_001233205.1
3468 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Lissencephaly syndrome, Norman-Roberts type.



Publications
Articles associated with genes and sequences of this homology group.

VEGF activates NR2B phosphorylation through Dab1 pathway.
Howell KR, et al. Neurosci Lett 552, 30-4 (2013).
Heterotopic reelin in human nodular heterotopia: a neuropathological study.
Rossini L, et al. Epileptic Disord 14, 398-402 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Reeler (cd08544)
  Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins.
Reelin_subrepeat_like (cl15240)
  Tandem repeat subunit of reelin and related proteins.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
EGF_2 (pfam07974)
  EGF-like domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Reeler_cohesin_like (cl14606)
  Domains similar to the eukaryotic reeler domain and bacterial cohesins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Reln includes H.sapiens RELN and R.norvegicus Reln.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 9 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Branchiopoda - crustaceans (1 transcript, 1 species)

 

 

 

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