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HomoloGene:22659. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   IKZF2,  H.sapiens
IKAROS family zinc finger 2 (Helios)
526 aa
   IKZF2,  P.troglodytes
IKAROS family zinc finger 2 (Helios)
532 aa
   IKZF2,  M.mulatta
IKAROS family zinc finger 2 (Helios)
532 aa
   IKZF2,  C.lupus
IKAROS family zinc finger 2 (Helios)
532 aa
   IKZF2,  B.taurus
IKAROS family zinc finger 2 (Helios)
532 aa
   Ikzf2,  M.musculus
IKAROS family zinc finger 2
526 aa
   Ikzf2,  R.norvegicus
IKAROS family zinc finger 2
313 aa
   IKZF2,  G.gallus
IKAROS family zinc finger 2 (Helios)
563 aa
   ikzf2,  X.tropicalis
IKAROS family zinc finger 2 (Helios)
523 aa
   si:zfos-1425h8.1,  D.rerio
495 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Phenotypic and functional properties of Helios+ regulatory T cells.
Zabransky DJ, et al. PLoS One 7, e34547 (2012).
Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies.
Rebollo A & Schmitt C. Immunol Cell Biol 81, 171-5 (2003).
Expression of a unique helios isoform in human leukemia cells.
Sun L, et al. Leuk Lymphoma 43, 841-9 (2002).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
zf-H2C2_2 (pfam13465)
  Zinc-finger double domain.
zf-C2H2 (pfam00096)
  Zinc finger, C2H2 type.
zf-H2C2_2 (cl19539)
  Zinc-finger double domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ikzf2 includes H.sapiens IKZF2 and R.norvegicus Ikzf2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 9 species)
Actinopterygii - bony fishes (6 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)




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