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HomoloGene:21398. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   UTRN,  H.sapiens
utrophin
    NP_009055.2
3433 aa
   UTRN,  P.troglodytes
utrophin
    XP_001172875.1
3433 aa
   UTRN,  M.mulatta
utrophin-like
    XP_002808443.1
3434 aa
   UTRN,  C.lupus
utrophin
    NP_001012395.1
3432 aa
   UTRN,  B.taurus
utrophin
    NP_001265490.1
3434 aa
   Utrn,  M.musculus
utrophin
    NP_035812.3
3430 aa
   Utrn,  R.norvegicus
utrophin
    NP_037202.1
3419 aa
   UTRN,  G.gallus
utrophin
    XP_419648.4
3493 aa
   utrn,  X.tropicalis
utrophin
    XP_002934506.2
3541 aa
   LOC572406,  D.rerio
utrophin-like
    XP_005161957.1
2516 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Autophagy-mediated turnover of dynamin-related protein 1.
Purnell PR & Fox HS. BMC Neurosci 14, 86 (2013).
Tissue expression and actin binding of a novel N-terminal utrophin isoform.
Zuellig RA, et al. J Biomed Biotechnol 2011, 904547 (2011).
Translational regulation of utrophin by miRNAs.
Basu U, et al. PLoS One 6, e29376 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
ZZ (cl00295)
  Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
SPEC (cl02488)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
CH (cl00030)
  Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
Spectrin (cl02488)
  Spectrin repeat.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Utrn includes H.sapiens UTRN and R.norvegicus Utrn.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 9 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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