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HomoloGene:10743. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   RTN4,  H.sapiens
reticulon 4
    NP_065393.1
1192 aa
   RTN4,  M.mulatta
reticulon 4
    XP_001112090.2
1193 aa
   RTN4,  C.lupus
reticulon 4
    XP_531828.2
1205 aa
   RTN4,  B.taurus
reticulon 4
    NP_001106692.1
379 aa
   Rtn4,  M.musculus
reticulon 4
    NP_918943.1
1162 aa
   Rtn4,  R.norvegicus
reticulon 4
    NP_114019.1
1163 aa
   LOC101749579,  G.gallus
reticulon-4-like
    XP_004940228.1
828 aa
   rtn4,  X.tropicalis
reticulon 4
    NP_001161159.1
1063 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Nogo-A is a negative regulator of CNS angiogenesis.
Wälchli T, et al. Proc Natl Acad Sci U S A 110, E1943-52 (2013).
Nogo-A downregulation improves insulin secretion in mice.
Bonal CB, et al. Diabetes 62, 1443-52 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rtn4 includes H.sapiens RTN4 and R.norvegicus Rtn4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (32 transcripts, 18 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Aves - birds (3 transcripts, 2 species)
Amniota - vertebrates (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (4 transcripts, 2 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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