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HomoloGene:37322. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MAN2B1,  H.sapiens
mannosidase, alpha, class 2B, member 1
    NP_000519.2
1011 aa
   MAN2B1,  P.troglodytes
mannosidase, alpha, class 2B, member 1
    XP_003316198.2
704 aa
   LOC716173,  M.mulatta
lysosomal alpha-mannosidase-like
    XP_002801133.1
936 aa
   MAN2B1,  C.lupus
mannosidase, alpha, class 2B, member 1
    XP_005632890.1
1008 aa
   MAN2B1,  B.taurus
mannosidase, alpha, class 2B, member 1
    NP_776986.2
999 aa
   Man2b1,  M.musculus
mannosidase 2, alpha B1
    NP_034894.2
1013 aa
   Man2b1,  R.norvegicus
mannosidase, alpha, class 2B, member 1
    NP_955436.1
1009 aa
   man2b1,  X.tropicalis
mannosidase, alpha, class 2B, member 1
    NP_001072469.1
995 aa
   man2b1,  D.rerio
mannosidase, alpha, class 2B, member 1
    NP_001014354.1
982 aa
   LM408,  D.melanogaster
Lysosomal alpha-mannosidase
    NP_609408.1
1080 aa
   AgaP_AGAP008584,  A.gambiae
AgaP_AGAP008584
    XP_557731.3
1138 aa
   aman-1,  C.elegans
aman-1
    NP_508811.1
955 aa
   AT5G13980,  A.thaliana
AT5G13980
    NP_196902.2
1024 aa
   Os11g0525600,  O.sativa
Os11g0525600
    NP_001067993.1
1020 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Mannosidosis, alpha-, types I and II.



Publications
Articles associated with genes and sequences of this homology group.

Expression, purification and preliminary crystallographic analysis of Drosophila melanogaster lysosomal α-mannosidase.
Nemčovičová I, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 68, 965-70 (2012).
Alpha-Mannosidosis
Malm D, et al. (1993).
Alpha-mannosidosis and mutational analysis in a Turkish patient.
Olmez A, et al. Turk J Pediatr 45, 46-50 (2003).
Lysosomal alpha-D-mannosidase.
Beccari T, et al. Biosci Rep 19, 157-62 (1999).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Glyco_hydro_38C (pfam07748)
  Glycosyl hydrolases family 38 C-terminal domain.
Glyco_hydro_38C (pfam07748)
  Glycosyl hydrolases family 38 C-terminal domain.
Alpha-mann_mid (cl08536)
  Alpha mannosidase, middle domain.
GH38-57_N_LamB_YdjC_SF (cl17191)
  Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Man2b1 includes H.sapiens MAN2B1 and R.norvegicus Man2b1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (79 transcripts, 35 species)
Liliopsida - monocots (19 transcripts, 9 species)
Coniferopsida - conifers (4 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Arthropoda
Insecta - insects (28 transcripts, 12 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (3 transcripts, 1 species)
Maxillopoda - crustaceans (3 transcripts, 1 species)

Chordata
Mammalia - mammals (14 transcripts, 13 species)
Actinopterygii - bony fishes (10 transcripts, 8 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (2 transcripts, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

 

 

 

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