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HomoloGene:1045. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DKC1,  H.sapiens
dyskeratosis congenita 1, dyskerin
    NP_001354.1
514 aa
   DKC1,  P.troglodytes
dyskeratosis congenita 1, dyskerin
    XP_521345.3
516 aa
   DKC1,  M.mulatta
dyskeratosis congenita 1, dyskerin
    XP_001090867.2
514 aa
   DKC1,  C.lupus
dyskeratosis congenita 1, dyskerin
    XP_549382.2
517 aa
   DKC1,  B.taurus
dyskeratosis congenita 1, dyskerin
    NP_001098865.1
506 aa
   Dkc1,  M.musculus
dyskeratosis congenita 1, dyskerin
    NP_001025478.1
509 aa
   Dkc1,  R.norvegicus
dyskeratosis congenita 1, dyskerin
    NP_596910.1
509 aa
   DKC1,  G.gallus
dyskeratosis congenita 1, dyskerin
    NP_001026286.1
516 aa
   dkc1,  X.tropicalis
dyskeratosis congenita 1, dyskerin
    XP_004916830.1
561 aa
   dkc1,  D.rerio
dyskeratosis congenita 1, dyskerin
    NP_001028279.2
506 aa
   Nop60B,  D.melanogaster
Nucleolar protein at 60B
    NP_001163289.1
508 aa
   AgaP_AGAP004739,  A.gambiae
AgaP_AGAP004739
    XP_318082.4
521 aa
   K01G5.5,  C.elegans
K01G5.5
    NP_499370.1
445 aa
   CBF5,  S.cerevisiae
CBF5
    NP_013276.1
483 aa
   KLLA0D04796g,  K.lactis
KLLA0D04796g
    XP_453273.1
474 aa
   AGOS_AAL007C,  E.gossypii
AGOS_AAL007C
    NP_982535.1
485 aa
   cbf5,  S.pombe
cbf5
    NP_594878.1
474 aa
   MGG_07518,  M.oryzae
MGG_07518
    XP_003711432.1
485 aa
   NCU01290,  N.crassa
NCU01290
    XP_960827.1
480 aa
   NAP57,  A.thaliana
NAP57
    NP_191274.1
565 aa
   Os03g0370500,  O.sativa
Os03g0370500
    NP_001050199.1
591 aa
   Os07g0636000,  O.sativa
Os07g0636000
    NP_001060391.1
600 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hoyeraal-Hreidarsson syndrome.
Dyskeratosis congenita-1.



Publications
Articles associated with genes and sequences of this homology group.

Intron retention: a human DKC1 gene common splicing event.
Turano M, et al. Biochem Cell Biol 91, 506-12 (2013).
DKC1 gene mutations in human sporadic cancer.
Penzo M, et al. Histol Histopathol 28, 365-72 (2013).
A new human dyskerin isoform with cytoplasmic localization.
Angrisani A, et al. Biochim Biophys Acta 1810, 1361-8 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PUA (pfam01472)
  PUA domain.
DKCLD (pfam08068)
  DKCLD (NUC011) domain.
DKCLD (pfam08068)
  DKCLD (NUC011) domain.
PseudoU_synth (cl00130)
  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi).
PUA (cl00607)
  PUA domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dkc1 includes H.sapiens DKC1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (16 transcripts, 11 species)
Mammalia - mammals (13 transcripts, 12 species)
Ascidiacea - tunicates (4 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (17 transcripts, 13 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (32 transcripts, 25 species)
Liliopsida - monocots (17 transcripts, 8 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (3 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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