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HomoloGene:123820. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HLA-DQA1,  H.sapiens
major histocompatibility complex, class II, DQ alpha 1
    NP_002113.2
255 aa
   PATR-DQA1,  P.troglodytes
major histocompatibility complex, class II, DQ alpha 1
    XP_003950844.1
255 aa
   HLA-DQA1,  M.mulatta
major histocompatibility complex, class II, DQ alpha 1-like
    XP_001115365.1
254 aa
   MAMU-DQA1,  M.mulatta
major histocompatibility complex, class II, DQ alpha 1
    NP_001127767.1
255 aa
   LOC100848815,  B.taurus
SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like
    XP_003587740.1
255 aa
   H2-Aa,  M.musculus
histocompatibility 2, class II antigen A, alpha
    NP_034508.2
256 aa
   RT1-Ba,  R.norvegicus
RT1 class II, locus Ba
    NP_001008831.1
255 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Celiac disease, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

HLA class II locus and susceptibility to podoconiosis.
Tekola Ayele F, et al. N Engl J Med 366, 1200-8 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MHC_II_alpha (cl03058)
  Class II MHC glycoproteins are expressed on the surface of antigen-presenting cells (APC), including macrophages, dendritic cells and B cells. MHC II proteins present peptide antigens that originate extracellularly from foreign bodies such as bacteria. Proteins from the pathogen are degraded into peptide fragments within the APC, which sequesters these fragments into the endosome so they can bind to MHC class II proteins, before being transported to the cell surface. MHC class II receptors display antigens for recognition by helper T cells (stimulate development of B cell clones) and inflammatory T cells (cause the release of lymphokines that attract other cells to site of infection).
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus H2-Aa includes H.sapiens HLA-DQA1 and R.norvegicus RT1-Ba.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (35 transcripts, 12 species)

 

 

 

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