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HomoloGene:332. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CASR,  H.sapiens
calcium-sensing receptor
    NP_001171536.1
1088 aa
   CASR,  P.troglodytes
calcium-sensing receptor
    XP_516689.2
1078 aa
   CASR,  M.mulatta
calcium-sensing receptor
    XP_001112009.2
1062 aa
   CASR,  C.lupus
calcium-sensing receptor
    NP_001074978.1
1075 aa
   CASR,  B.taurus
calcium-sensing receptor
    NP_776427.1
1085 aa
   Casr,  M.musculus
calcium-sensing receptor
    NP_038831.2
1079 aa
   Casr,  R.norvegicus
calcium-sensing receptor
    NP_058692.1
1079 aa
   CASR,  G.gallus
calcium-sensing receptor
    XP_416491.3
1059 aa
   LOC100496505,  X.tropicalis
extracellular calcium-sensing receptor-like
    XP_004919842.1
1046 aa
   LOC560607,  D.rerio
extracellular calcium-sensing receptor-like
    XP_689097.1
946 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hypocalciuric hypercalcemia, type I.
Hypocalcemia, autosomal dominant.
Hypoparathyroidism, familial isolated.
Hyperparathyroidism, neonatal.
Hypocalcemia, autosomal dominant, with Bartter syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Development of a calcium-sensing receptor molecular imaging agent.
Yusof AM, et al. Surgery 154, 1378-84; discussion 1384 (2013).
Calcium-sensing in the kidney.
Houillier P. Curr Opin Nephrol Hypertens 22, 566-71 (2013).
Calcium-sensing receptor (CaSR) mutations and disorders of calcium, electrolyte and water metabolism.
Hannan FM & Thakker RV. Best Pract Res Clin Endocrinol Metab 27, 359-71 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_3 (pfam00003)
  7 transmembrane sweet-taste receptor of 3 GCPR.
NCD3G (pfam07562)
  Nine Cysteines Domain of family 3 GPCR.
Periplasmic_Binding_Protein_Type_1 (cl10011)
  Type 1 periplasmic binding fold superfamily.
7tm_3 (pfam00003)
  7 transmembrane sweet-taste receptor of 3 GCPR.
NCD3G (pfam07562)
  Nine Cysteines Domain of family 3 GPCR.
Periplasmic_Binding_Protein_Type_1 (cl10011)
  Type 1 periplasmic binding fold superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Casr includes H.sapiens CASR and R.norvegicus Casr.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (8 transcripts, 4 species)
Ascidiacea - tunicates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 1 species)

 

 

 

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