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HomoloGene:37351. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ACE,  H.sapiens
angiotensin I converting enzyme
    NP_000780.1
1306 aa
   ACE,  P.troglodytes
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
    NP_001008995.1
1304 aa
   LOC100428661,  M.mulatta
angiotensin-converting enzyme-like
    XP_002800616.1
1532 aa
   LOC610668,  C.lupus
angiotensin-converting enzyme-like
    XP_003639297.1
1315 aa
   ACE,  B.taurus
angiotensin I converting enzyme
    NP_001193597.1
1306 aa
   Ace,  M.musculus
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
    NP_997507.1
1312 aa
   Ace,  R.norvegicus
angiotensin I converting enzyme
    NP_036676.1
1313 aa
   ACE,  G.gallus
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
    NP_001161204.1
1281 aa
   ace,  X.tropicalis
angiotensin I converting enzyme
    NP_001116882.1
1284 aa
   ace,  D.rerio
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
    XP_694336.5
1324 aa
   ANCE9,  A.gambiae
ANCE9
    XP_313865.3
1225 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Alzheimer disease, susceptibility to.
Angiotensin I-converting enzyme, benign serum increase.
Myocardial infarction, susceptibility to.
SARS, progression of.
Renal tubular dysgenesis.
Diabetic nephropathy, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Genetic ACE I/D polymorphism and recurrence of atrial fibrillation after catheter ablation.
Ueberham L, et al. Circ Arrhythm Electrophysiol 6, 732-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Peptidase_M2 (pfam01401)
  Angiotensin-converting enzyme.
GluZincin (cl14813)
  Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ace includes H.sapiens ACE and R.norvegicus Ace.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 11 species)
Actinopterygii - bony fishes (14 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 4 species)
Arachnida - arachnids (4 transcripts, 1 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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