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HomoloGene:4137. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TP53BP1,  H.sapiens
tumor protein p53 binding protein 1
    NP_001135452.1
1977 aa
   TP53BP1,  P.troglodytes
tumor protein p53 binding protein 1
    XP_523062.3
1977 aa
   TP53BP1,  M.mulatta
tumor protein p53 binding protein 1
    XP_001107285.2
1977 aa
   TP53BP1,  C.lupus
tumor protein p53 binding protein 1
    XP_849774.1
1976 aa
   TP53BP1,  B.taurus
tumor protein p53 binding protein 1
    NP_001193326.1
1966 aa
   Trp53bp1,  M.musculus
transformation related protein 53 binding protein 1
    NP_038763.3
1969 aa
   Tp53bp1,  R.norvegicus
tumor protein p53 binding protein 1
    XP_003749608.1
1972 aa
   TP53BP1,  G.gallus
tumor protein p53 binding protein 1
    XP_004944052.1
1907 aa
   tp53bp1,  X.tropicalis
tumor protein p53 binding protein 1
    XP_004912688.1
2185 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Double-strand break repair: 53BP1 comes into focus.
Panier S & Boulton SJ. Nat Rev Mol Cell Biol 15, 7-18 (2014).
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.
Fradet-Turcotte A, et al. Nature 499, 50-4 (2013).
[Correlation of 53BP1 gene mutation with prostatic adenocarcinoma].
Du R, et al. Zhonghua Bing Li Xue Za Zhi 40, 449-53 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
TUDOR (cl02573)
  Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Trp53bp1 includes H.sapiens TP53BP1 and R.norvegicus Tp53bp1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (20 transcripts, 12 species)
Actinopterygii - bony fishes (8 transcripts, 5 species)
Aves - birds (2 transcripts, 1 species)

 

 

 

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