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HomoloGene:2903. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   EIF2B5,  H.sapiens
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
    NP_003898.2
721 aa
   EIF2B5,  P.troglodytes
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
    XP_001139517.1
721 aa
   EIF2B5,  M.mulatta
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
    XP_001104122.1
721 aa
   EIF2B5,  C.lupus
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
    XP_003640192.1
721 aa
   EIF2B5,  B.taurus
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
    XP_002684924.1
728 aa
   Eif2b5,  M.musculus
eukaryotic translation initiation factor 2B, subunit 5 epsilon
    NP_758469.1
717 aa
   Eif2b5,  R.norvegicus
eukaryotic translation initiation factor 2B, subunit 5 epsilon
    NP_620221.2
716 aa
   EIF2B5,  G.gallus
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
    XP_422755.3
707 aa
   eif2b5,  X.tropicalis
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
    XP_002935185.2
716 aa
   eif2b5,  D.rerio
eukaryotic translation initiation factor 2B, subunit 5 epsilon
    NP_001107069.1
703 aa
   eIF2B-epsilon,  D.melanogaster
eIF2B-epsilon
    NP_996329.1
669 aa
   AgaP_AGAP000082,  A.gambiae
AgaP_AGAP000082
    XP_001687758.1
671 aa
   GCD6,  S.cerevisiae
GCD6
    NP_010497.3
712 aa
   KLLA0A04235g,  K.lactis
KLLA0A04235g
    XP_451187.1
736 aa
   AGOS_AGL094W,  E.gossypii
AGOS_AGL094W
    NP_986572.1
731 aa
   tif225,  S.pombe
tif225
    NP_594285.1
678 aa
   MGG_03517,  M.oryzae
MGG_03517
    XP_003716402.1
733 aa
   NCU02414,  N.crassa
NCU02414
    XP_959596.1
746 aa
   AT4G18300,  A.thaliana
AT4G18300
    NP_193564.1
709 aa
   AT2G34970,  A.thaliana
AT2G34970
    NP_181042.1
730 aa
   AT3G02270,  A.thaliana
AT3G02270
    NP_186876.1
676 aa
   Os02g0812400,  O.sativa
Os02g0812400
    NP_001048478.1
732 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Leukoencephalopathy with vanishing white matter.
Ovarioleukodystrophy.



Publications
Articles associated with genes and sequences of this homology group.

Genotype-phenotype correlation in vanishing white matter disease.
van der Lei HD, et al. Neurology 75, 1555-9 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LbetaH (cl00160)
  Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
LbetaH (cl00160)
  Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
Glyco_tranf_GTA_type (cl11394)
  Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold.
W2 (cl17013)
  C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Eif2b5 includes H.sapiens EIF2B5 and R.norvegicus Eif2b5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (30 transcripts, 24 species)
Liliopsida - monocots (13 transcripts, 9 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chordata
Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (10 transcripts, 10 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 7 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Ascomycota
Eurotiomycetes - ascomycetes (3 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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