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HomoloGene:48448. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KDM5B,  H.sapiens
lysine (K)-specific demethylase 5B
    NP_006609.3
1544 aa
   KDM5B,  P.troglodytes
lysine (K)-specific demethylase 5B
    XP_514104.3
1681 aa
   LOC706437,  M.mulatta
lysine-specific demethylase 5B-like
    XP_002808303.1
1578 aa
   KDM5B,  C.lupus
lysine (K)-specific demethylase 5B
    XP_005622266.1
1663 aa
   KDM5B,  B.taurus
lysine (K)-specific demethylase 5B
    XP_002694248.2
1619 aa
   Kdm5b,  M.musculus
lysine (K)-specific demethylase 5B
    NP_690855.2
1544 aa
   Kdm5b,  R.norvegicus
lysine (K)-specific demethylase 5B
    NP_001100647.1
1544 aa
   KDM5B,  G.gallus
lysine (K)-specific demethylase 5B
    NP_001026200.1
1522 aa
   kdm5b,  X.tropicalis
lysine (K)-specific demethylase 5B
    XP_004910700.1
1577 aa
   kdm5bb,  D.rerio
lysine (K)-specific demethylase 5Bb
    NP_001002166.1
1503 aa
   rbr-2,  C.elegans
rbr-2
    NP_502032.2
1477 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Extended self-renewal and accelerated reprogramming in the absence of Kdm5b.
Kidder BL, et al. Mol Cell Biol 33, 4793-810 (2013).
JARID1B expression in human melanoma and benign melanocytic skin lesions.
Ku┼║bicki L, et al. Melanoma Res 23, 8-12 (2013).
JARID1B protein expression and prognostic implications in uveal melanoma.
Radberger P, et al. Invest Ophthalmol Vis Sci 53, 4442-9 (2012).
Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B.
Guo X, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 67, 907-10 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHD (pfam00628)
  PHD-finger.
JmjC (pfam02373)
  JmjC domain, hydroxylase.
JmjN (cl15840)
  jmjN domain.
ARID (pfam01388)
  ARID/BRIGHT DNA binding domain.
zf-C5HC2 (pfam02928)
  C5HC2 zinc finger.
PLU-1 (pfam08429)
  PLU-1-like protein.
PHD (cl17445)
  PHD-finger.
zf-C5HC2 (pfam02928)
  C5HC2 zinc finger.
PLU-1 (pfam08429)
  PLU-1-like protein.
ARID (cl02633)
  ARID/BRIGHT DNA binding domain.
PHD (cl17445)
  PHD-finger.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kdm5b includes H.sapiens KDM5B and R.norvegicus Kdm5b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 12 species)
Actinopterygii - bony fishes (13 transcripts, 7 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Isoetopsida - club-mosses (2 transcripts, 1 species)
Eudicotyledons - eudicots (1 transcript, 1 species)

 

 

 

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