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HomoloGene:3783. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   ABL1,  H.sapiens
c-abl oncogene 1, non-receptor tyrosine kinase
1149 aa
   ABL1,  P.troglodytes
c-abl oncogene 1, non-receptor tyrosine kinase
1149 aa
   ABL1,  C.lupus
c-abl oncogene 1, non-receptor tyrosine kinase
1150 aa
   ABL1,  B.taurus
c-abl oncogene 1, non-receptor tyrosine kinase
1151 aa
   Abl1,  M.musculus
c-abl oncogene 1, non-receptor tyrosine kinase
1142 aa
   Abl1,  R.norvegicus
c-abl oncogene 1, non-receptor tyrosine kinase
1143 aa
   LOC100909750,  R.norvegicus
tyrosine-protein kinase ABL1-like
1124 aa
   ABL1,  G.gallus
c-abl oncogene 1, non-receptor tyrosine kinase
1144 aa
   abl1,  X.tropicalis
c-abl oncogene 1, non-receptor tyrosine kinase
1119 aa
   abl1,  D.rerio
c-abl oncogene 1, receptor tyrosine kinase
1079 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Leukemia, Philadelphia chromosome-positive, resistant to imatinib.

Articles associated with genes and sequences of this homology group.

Role of Abl in airway hyperresponsiveness and airway remodeling.
Cleary RA, et al. Respir Res 14, 105 (2013).
Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-cap.
Corbi-Verge C, et al. Proc Natl Acad Sci U S A 110, E3372-80 (2013).
Doxorubicin induces atypical NF-κB activation through c-Abl kinase activity in breast cancer cells.
Esparza-López J, et al. J Cancer Res Clin Oncol 139, 1625-35 (2013).
[ABL fusion gene].
Yamauchi T & Ueda T. Nihon Rinsho 70 Suppl 8, 41-4 (2012).
New concepts for CML clonality.
Khorashad JS, et al. Oncotarget 4, 7-8 (2013).
Explaining why Gleevec is a specific and potent inhibitor of Abl kinase.
Lin YL, et al. Proc Natl Acad Sci U S A 110, 1664-9 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Rubella_Capsid (pfam05750)
  Rubella capsid protein.
F_actin_bind (pfam08919)
  F-actin binding.
F_actin_bind (cl07494)
  F-actin binding.
F_actin_bind (cl07494)
  The F-actin binding domain forms a compact bundle of four antiparallel alpha-helices, which are arranged in a left-handed topology. Binding of F-actin to the F-actin binding domain may result in cytoplasmic retention and subcellular distribution of the protein, as well as possible inhibition of protein function.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Abl1 includes H.sapiens ABL1 and R.norvegicus Abl1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 8 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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