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HomoloGene:21375. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SCN1A,  H.sapiens
sodium channel, voltage-gated, type I, alpha subunit
    NP_001159435.1
2009 aa
   SCN1A,  P.troglodytes
sodium channel, voltage-gated, type I, alpha subunit
    XP_003309330.1
2009 aa
   SCN1A,  M.mulatta
sodium channel, voltage-gated, type I, alpha subunit
    XP_001101023.1
2008 aa
   SCN1A,  C.lupus
sodium channel, voltage-gated, type I, alpha subunit
    XP_005640320.1
2009 aa
   SCN1A,  B.taurus
sodium channel, voltage-gated, type I, alpha subunit
    NP_001180147.1
1998 aa
   Scn1a,  M.musculus
sodium channel, voltage-gated, type I, alpha
    NP_061203.2
1998 aa
   Scn1a,  R.norvegicus
sodium channel, voltage-gated, type I, alpha
    NP_110502.1
2009 aa
   SCN1A,  G.gallus
sodium channel, voltage-gated, type I, alpha subunit
    XP_003641634.1
2013 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Antiepileptic drugs, response to.
Epilepsy, generalized, with febrile seizures plus, type 2.
Febrile convulsions, familial, 3.
Epilepsy, intractable childhood, with generalized tonic-clonic seizures.
Epilepsy, severe myoclonic, of infancy.
Migraine, familial hemiplegic, 3.



Publications
Articles associated with genes and sequences of this homology group.

Mapping genetic modifiers of survival in a mouse model of Dravet syndrome.
Miller AR, et al. Genes Brain Behav 13, 163-72 (2014).
The SCN1A gene variants and epileptic encephalopathies.
Parihar R & Ganesh S. J Hum Genet 58, 573-80 (2013).
Sudden unexpected death in a mouse model of Dravet syndrome.
Kalume F, et al. J Clin Invest 123, 1798-808 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).
Na_channel_gate (cd13433)
  Inactivation gate of the voltage-gated sodium channel alpha subunits.
Ion_trans (pfam00520)
  Ion transport protein.
Na_trans_assoc (pfam06512)
  Sodium ion transport-associated.
DUF3451 (pfam11933)
  Domain of unknown function (DUF3451).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scn1a includes H.sapiens SCN1A and R.norvegicus Scn1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (21 transcripts, 10 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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