Display Settings:

Format

Send to:

Choose Destination

Links from PubMed

HomoloGene:2776. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SOCS1,  H.sapiens
suppressor of cytokine signaling 1
    NP_003736.1
211 aa
   SOCS1,  P.troglodytes
suppressor of cytokine signaling 1
    XP_001141793.1
211 aa
   SOCS1,  M.mulatta
suppressor of cytokine signaling 1
    XP_001104595.1
215 aa
   SOCS1,  C.lupus
suppressor of cytokine signaling 1
    XP_005622136.1
184 aa
   SOCS1,  B.taurus
suppressor of cytokine signaling 1
    XP_002698010.1
223 aa
   Socs1,  M.musculus
suppressor of cytokine signaling 1
    NP_001258532.1
212 aa
   Socs1,  R.norvegicus
suppressor of cytokine signaling 1
    NP_665886.1
212 aa
   SOCS1,  G.gallus
suppressor of cytokine signaling 1
    NP_001131120.1
207 aa
   socs1,  X.tropicalis
suppressor of cytokine signaling 1
    NP_001011327.1
211 aa
   socs1a,  D.rerio
suppressor of cytokine signaling 1a
    NP_001003467.1
201 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Role of suppressor of cytokine signaling-1 in murine atherosclerosis.
Grothusen C, et al. PLoS One 7, e51608 (2012).
Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells.
Parrillas V, et al. Cell Mol Life Sci 70, 545-58 (2013).
SOCS1 gene expression is increased in severe pulmonary tuberculosis.
Masood KI, et al. Scand J Immunol 76, 398-404 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SOCS (cl02533)
  SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
SOCS (cl02533)
  SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
SH2 (cl15255)
  Src homology 2 (SH2) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Socs1 includes H.sapiens SOCS1 and R.norvegicus Socs1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

Write to the Help Desk