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HomoloGene:47902. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   BLM,  H.sapiens
Bloom syndrome, RecQ helicase-like
1417 aa
   BLM,  P.troglodytes
Bloom syndrome, RecQ helicase-like
1417 aa
   BLM,  M.mulatta
Bloom syndrome, RecQ helicase-like
1416 aa
   BLM,  C.lupus
Bloom syndrome, RecQ helicase-like
1420 aa
   BLM,  B.taurus
Bloom syndrome, RecQ helicase-like
1430 aa
   Blm,  M.musculus
Bloom syndrome, RecQ helicase-like
1419 aa
   Blm,  R.norvegicus
Bloom syndrome, RecQ helicase-like
1411 aa
   BLM,  G.gallus
Bloom syndrome, RecQ helicase-like
1380 aa
   blm,  X.tropicalis
Bloom syndrome, RecQ helicase-like
1327 aa
   blm,  D.rerio
Bloom syndrome
1242 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Bloom syndrome.

Articles associated with genes and sequences of this homology group.

On BLM helicase in recombination-mediated telomere maintenance.
Rezazadeh S. Mol Biol Rep 40, 3049-64 (2013).
Non-Bloom syndrome-associated partial and total loss-of-function variants of BLM helicase.
Mirzaei H & Schmidt KH. Proc Natl Acad Sci U S A 109, 19357-62 (2012).
Augmented cell death with Bloom syndrome helicase deficiency.
Kaneko H, et al. Mol Med Rep 4, 607-9 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BDHCT (pfam08072)
  BDHCT (NUC031) domain.
HRDC (cl02578)
  HRDC domain.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
RQC (cl09632)
  RQC domain.
HRDC (cl02578)
  HRDC domain.
RQC (cl09632)
  RQC domain.
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Blm includes H.sapiens BLM and R.norvegicus Blm.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (17 transcripts, 12 species)
Actinopterygii - bony fishes (8 transcripts, 4 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Insecta - insects (4 transcripts, 3 species)

Trematoda - flatworms (1 transcript, 1 species)

Liliopsida - monocots (8 transcripts, 7 species)
Eudicotyledons - eudicots (7 transcripts, 6 species)

Peronosporales - oomycetes (1 transcript, 1 species)




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