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HomoloGene:32535. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   IFIH1,  H.sapiens
interferon induced with helicase C domain 1
    NP_071451.2
1025 aa
   IFIH1,  P.troglodytes
interferon induced with helicase C domain 1
    XP_003309348.1
1024 aa
   IFIH1,  M.mulatta
interferon induced with helicase C domain 1
    NP_001040588.1
1025 aa
   IFIH1,  C.lupus
interferon induced with helicase C domain 1
    XP_545493.2
1029 aa
   IFIH1,  B.taurus
interferon induced with helicase C domain 1
    XP_002685384.1
1021 aa
   Ifih1,  M.musculus
interferon induced with helicase C domain 1
    NP_082111.2
1025 aa
   Ifih1,  R.norvegicus
interferon induced with helicase C domain 1
    NP_001102669.1
1027 aa
   IFIH1,  G.gallus
interferon induced with helicase C domain 1
    NP_001180567.1
1001 aa
   ifih1,  X.tropicalis
interferon induced with helicase C domain 1
    XP_002933320.2
998 aa
   LOC565759,  D.rerio
novel protein similar to vertebrate interferon induced with helicase C domain 1 (IFIH1)
    XP_694124.4
997 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, insulin-dependent, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CARD_MDA5_1 (cd08818)
  Caspase activation and recruitment domain found in MDA5, first repeat.
CARD_MDA5_2 (cd08819)
  Caspase activation and recruitment domain found in MDA5, second repeat.
helicase_insert_domain (cl17041)
  helical domain inserted in SF2-type helicase domain in Hef-, MDA5- and FancM-like proteins.
RIG-I_C-RD (pfam11648)
  C-terminal domain of RIG-I.
HELICc (cd00079)
  Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
RIG-I_C-RD (pfam11648)
  C-terminal domain of RIG-I.
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.
DEXDc (cl17251)
  DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ifih1 includes H.sapiens IFIH1 and R.norvegicus Ifih1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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