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HomoloGene:22999. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ITGB1,  H.sapiens
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
    NP_002202.2
798 aa
   ITGB1,  P.troglodytes
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
    XP_003312561.1
798 aa
   ITGB1,  M.mulatta
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
    XP_002805655.1
755 aa
   ITGB1,  C.lupus
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
    XP_005617006.1
798 aa
   ITGB1,  B.taurus
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
    NP_776793.1
798 aa
   Itgb1,  M.musculus
integrin beta 1 (fibronectin receptor beta)
    NP_034708.1
798 aa
   Itgb1,  R.norvegicus
integrin, beta 1
    NP_058718.2
798 aa
   ITGB1,  G.gallus
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
    NP_001034343.2
803 aa
   itgb1,  X.tropicalis
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
    NP_989160.1
798 aa
   itgb1a,  D.rerio
integrin, beta 1a
    NP_001030143.1
798 aa
   itgb1b,  D.rerio
integrin, beta 1b
    NP_001030159.1
795 aa
   mys,  D.melanogaster
myospheroid
    NP_524793.2
846 aa
   INTB,  A.gambiae
INTB
    XP_311354.2
837 aa
   pat-3,  C.elegans
pat-3
    NP_497787.1
809 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
Structural gene for the β subunit of position-specific integrins 1 and 2, PS1 and PS2. Twenty-hour embryos (25oC) show middorsal herniation of brain and midgut, or both; abnormal somatic, visceral and pharyngeal muscles; and incomplete morphogenesis of yolk-filled midgut. Development of embryo normal up to 13 hr, even in embryos produced from homozygous germ-line clones (Wieschaus and Noell, 1986). Between 13 and 14.5 hr the first muscular contractions occur, while basement membrane is incomplete. (See FlyBase for complete description.)



Publications
Articles associated with genes and sequences of this homology group.

β1-integrin is essential for vasoregulation and smooth muscle survival in vivo.
Turlo KA, et al. Arterioscler Thromb Vasc Biol 33, 2325-35 (2013).
Overexpression of integrin-β1 in leiomyoma promotes cell spreading and proliferation.
Chen HM, et al. J Clin Endocrinol Metab 98, E837-46 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Integrin_b_cyt (pfam08725)
  Integrin beta cytoplasmic domain.
Integrin_beta (pfam00362)
  Integrin, beta chain.
Integrin_B_tail (pfam07965)
  Integrin beta tail domain.
Integrin_B_tail (pfam07965)
  Integrin beta tail domain.
Integrin_beta (cl17693)
  Integrin, beta chain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itgb1 includes H.sapiens ITGB1 and R.norvegicus Itgb1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (34 transcripts, 10 species)
Mammalia - mammals (23 transcripts, 16 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 9 species)
Arachnida - arachnids (3 transcripts, 2 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (6 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (3 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

 

 

 

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