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HomoloGene:68998. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ARX,  H.sapiens
aristaless related homeobox
    NP_620689.1
562 aa
   ARX,  M.mulatta
aristaless related homeobox
    XP_001091313.1
562 aa
   ARX,  C.lupus
aristaless related homeobox
    NP_001108138.1
574 aa
   Arx,  M.musculus
aristaless related homeobox
    NP_031518.2
564 aa
   Arx,  R.norvegicus
aristaless related homeobox
    NP_001093644.1
566 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Proud syndrome.
Lissencephaly, X-linked with ambiguous genitalia.
Mental retardation, X-linked 36.
Mental retardation, X-linked 36/43/54.
Mental retardation, X-linked 43.
Myoclonic epilepsy with mental retardation and spasticity.
Infantile spasm syndrome.
Partington syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Expanding the phenotype associated with missense mutations of the ARX gene.
Charzewska A, et al. Am J Med Genet A 161A, 1813-6 (2013).
Novel mutation in ARX associated with early hand preference and a mild phenotype.
Kuwaik GA, et al. J Dev Behav Pediatr 33, 586-8 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
OAR (pfam03826)
  OAR domain.
OAR (pfam03826)
  OAR domain.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Arx includes H.sapiens ARX and R.norvegicus Arx.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 6 species)
Amphibia - amphibians (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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