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HomoloGene:1094. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   EP300,  H.sapiens
E1A binding protein p300
    NP_001420.2
2414 aa
   EP300,  P.troglodytes
E1A binding protein p300
    NP_001231599.1
2411 aa
   EP300,  M.mulatta
E1A binding protein p300
    XP_001102844.1
2414 aa
   EP300,  C.lupus
E1A binding protein p300
    XP_003431544.1
2428 aa
   Ep300,  M.musculus
E1A binding protein p300
    NP_808489.4
2412 aa
   Ep300,  R.norvegicus
E1A binding protein p300
    XP_006242208.1
2398 aa
   EP300,  G.gallus
E1A binding protein p300
    XP_004937767.1
2450 aa
   ep300,  X.tropicalis
E1A binding protein p300
    XP_004913856.1
2485 aa
   ep300b,  D.rerio
E1A binding protein p300 b
    XP_003198146.2
2629 aa
   ep300a,  D.rerio
E1A binding protein p300 a
    XP_005156233.1
2680 aa
   LOC100537254,  D.rerio
histone acetyltransferase p300-like
    XP_003199646.2
2207 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Colorectal cancer.
Rubinstein-Taybi syndrome.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
KIX (pfam02172)
  KIX domain.
DUF902 (pfam06001)
  Domain of Unknown Function (DUF902).
zf-TAZ (pfam02135)
  TAZ zinc finger.
KAT11 (pfam08214)
  Histone acetylation protein.
Creb_binding (pfam09030)
  Creb binding.
ZZ (cl00295)
  Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
KIX (pfam02172)
  KIX domain.
DUF902 (pfam06001)
  Domain of Unknown Function (DUF902).
Fork_head_N (pfam08430)
  Forkhead N-terminal region.
Creb_binding (pfam09030)
  Creb binding.
KAT11 (cl02120)
  Histone acetylation protein.
Bromodomain (cl02556)
  Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
zf-TAZ (cl02660)
  TAZ zinc finger.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ep300 includes H.sapiens EP300 and R.norvegicus Ep300.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (23 transcripts, 8 species)
Mammalia - mammals (20 transcripts, 10 species)
Aves - birds (5 transcripts, 2 species)
Amniota - vertebrates (3 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (3 transcripts, 3 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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