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HomoloGene:38268. Gene conserved in Bilateria Download ,
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CDC37,  H.sapiens
cell division cycle 37
    NP_008996.1
378 aa
   CDC37,  P.troglodytes
cell division cycle 37 homolog (S. cerevisiae)
    XP_003953416.1
350 aa
   CDC37,  M.mulatta
cell division cycle 37 homolog (S. cerevisiae)
    XP_001105596.2
378 aa
   CDC37,  C.lupus
cell division cycle 37
    XP_854103.1
380 aa
   CDC37,  B.taurus
cell division cycle 37 homolog (S. cerevisiae)
    NP_001030415.1
380 aa
   Cdc37,  M.musculus
cell division cycle 37
    NP_058022.1
379 aa
   Cdc37,  R.norvegicus
cell division cycle 37
    NP_446195.1
379 aa
   cdc37,  X.tropicalis
cell division cycle 37
    NP_001015912.1
371 aa
   cdc37,  D.rerio
cell division cycle 37 homolog (S. cerevisiae)
    NP_957332.1
367 aa
   Cdc37,  D.melanogaster
Cdc37
    NP_477006.1
389 aa
   AgaP_AGAP001914,  A.gambiae
AgaP_AGAP001914
    XP_321151.4
392 aa
   cdc-37,  C.elegans
cdc-37
    NP_001040821.1
403 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy.
Sreeramulu S, et al. J Biol Chem 284, 3885-96 (2009).
A client-binding site of Cdc37.
Terasawa K & Minami Y. FEBS J 272, 4684-90 (2005).
Fission yeast Cdc37 is required for multiple cell cycle functions.
Westwood PK, et al. Mol Genet Genomics 271, 82-90 (2004).
Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.
Siligardi G, et al. J Biol Chem 277, 20151-9 (2002).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CDC37_N (cl03951)
  Cdc37 N terminal kinase binding.
CDC37_N (cl03951)
  Cdc37 N terminal kinase binding.
CDC37_M (cl07248)
  Cdc37 Hsp90 binding domain.
CDC37_C (cl07247)
  Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cdc37 includes H.sapiens CDC37 and R.norvegicus Cdc37.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (15 transcripts, 11 species)
Mammalia - mammals (11 transcripts, 10 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 13 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (2 transcripts, 1 species)

Streptophyta
Liliopsida - monocots (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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