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HomoloGene:124414. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MYH6,  H.sapiens
myosin, heavy chain 6, cardiac muscle, alpha
    NP_002462.2
1939 aa
   MYH6,  P.troglodytes
myosin, heavy chain 6, cardiac muscle, alpha
    XP_003952494.1
1928 aa
   MYH6,  M.mulatta
myosin, heavy chain 6, cardiac muscle, alpha
    XP_001102827.2
1937 aa
   MYH6,  C.lupus
myosin, heavy chain 6, cardiac muscle, alpha
    XP_003435121.2
1942 aa
   MYH6,  B.taurus
myosin, heavy chain 6, cardiac muscle, alpha
    XP_002690549.1
1927 aa
   Myh6,  M.musculus
myosin, heavy polypeptide 6, cardiac muscle, alpha
    NP_034986.1
1938 aa
   Myh6,  R.norvegicus
myosin, heavy chain 6, cardiac muscle, alpha
    NP_058935.2
1939 aa
   MYH15,  G.gallus
myosin, heavy chain 15
    NP_990097.1
1937 aa
   myh6,  X.tropicalis
myosin, heavy chain 6, cardiac muscle, alpha
    XP_004910815.1
1941 aa
   myh6,  D.rerio
myosin, heavy polypeptide 6, cardiac muscle, alpha
    NP_942118.1
1936 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Atrial septal defect 3.
Cardiomyopathy, familial hypertrophic.



Publications
Articles associated with genes and sequences of this homology group.

Molecular biological analysis of cardiac effect of high temperature in rats.
Nakagawa Y, et al. Leg Med (Tokyo) 14, 63-8 (2012).
Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.
Palmer BM, et al. Am J Physiol Heart Circ Physiol 294, H1939-47 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Myosin_N (pfam02736)
  Myosin N-terminal SH3-like domain.
TMPIT (pfam07851)
  TMPIT-like protein.
PRK15374 (PRK15374)
  pathogenicity island 1 effector protein SipB; Provisional.
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
MM_CoA_mutase (cl00817)
  Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of ...
SPEC (cl02488)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Myosin_N (pfam02736)
  Myosin N-terminal SH3-like domain.
BDV_P24 (pfam06595)
  Borna disease virus P24 protein.
TMF_TATA_bd (pfam12325)
  TATA element modulatory factor 1 TATA binding.
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
MIT_CorA-like (cl00459)
  metal ion transporter CorA-like divalent cation transporter superfamily.
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myh6 includes H.sapiens MYH6 and R.norvegicus Myh6.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (55 transcripts, 12 species)
Mammalia - mammals (14 transcripts, 8 species)
Amphibia - amphibians (12 transcripts, 2 species)
Ascidiacea - tunicates (7 transcripts, 3 species)
Cephalochordata - lancelets (5 transcripts, 1 species)
Amniota - vertebrates (3 transcripts, 1 species)
Aves - birds (2 transcripts, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (3 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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