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HomoloGene:4060. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   LAMA5,  H.sapiens
laminin, alpha 5
3695 aa
   LAMA5,  P.troglodytes
laminin, alpha 5
1758 aa
   LAMA5,  C.lupus
laminin, alpha 5
2087 aa
   LAMA5,  B.taurus
laminin, alpha 5
3689 aa
   Lama5,  M.musculus
laminin, alpha 5
3718 aa
   Lama5,  R.norvegicus
laminin, alpha 5
3713 aa
   LAMA5,  G.gallus
laminin, alpha 5
3808 aa
   lama5,  X.tropicalis
laminin, alpha 5
1649 aa
   lama5,  D.rerio
laminin, alpha 5
3664 aa
   LanA,  D.melanogaster
Laminin A
3712 aa
   AgaP_AGAP004993,  A.gambiae
3704 aa
   epi-1,  C.elegans
3704 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Laminin_II (pfam06009)
  Laminin Domain II.
MA (smart00283)
  Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).
Laminin_EGF (pfam00053)
  Laminin EGF-like (Domains III and V).
Laminin_I (pfam06008)
  Laminin Domain I.
ALIX_LYPXL_bnd (pfam13949)
  ALIX V-shaped domain binding to HIV.
COG1340 (COG1340)
  Uncharacterized archaeal coiled-coil protein [Function unknown].
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Laminin_B (cl02548)
  Laminin B (Domain IV).
CBM6-CBM35-CBM36_like (cl14880)
  Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily.
Laminin_II (pfam06009)
  Laminin Domain II.
Laminin_N (cl02806)
  Laminin N-terminal (Domain VI).
CBM6-CBM35-CBM36_like (cl14880)
  Carbohydrate binding module family 6 (CBM6, family 6 CBM), also known as cellulose binding domain family VI (CBD VI), and related CBMs (CBM35 and CBM36). These are non-catalytic carbohydrate binding domains found in a range of enzymes that display activities against a diverse range of carbohydrate targets, including mannan, xylan, beta-glucans, cellulose, agarose, and arabinans. These domains facilitate the strong binding of the appended catalytic modules to their dedicated, insoluble substrates. Many of these CBMs are associated with glycoside hydrolase (GH) domains. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. CBM36s are calcium-dependent xylan binding domains. CBM35s display conserved specificity through extensive sequence similarity, but divergent function through their appended catalytic modules. This alignment model also contains the C-terminal domains of bacterial insecticidal toxins, where they may be involved in determining insect specificity through carbohydrate binding functionality.
LamG (cl17353)
  Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
EGF_Lam (cl19065)
  Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lama5 includes H.sapiens LAMA5 and R.norvegicus Lama5.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)

Insecta - insects (7 transcripts, 6 species)

Echinoidea - sea urchins (4 transcripts, 2 species)

Gastropoda - gastropods (1 transcript, 1 species)

Chromadorea - nematodes (1 transcript, 1 species)




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